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You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
3909	MLS000331633	C22H15NO5	373.364	6 / 0	3.9	Yes
5864	MLS000557918	C20H24N4O2	352.438	4 / 1	3.7	Yes
7215	MLS000779074	C20H19NO3	321.376	4 / 1	3.7	Yes
7493	2-Benzylidene-1,2-dihydro-indol-3-one	C15H11NO	221.259	2 / 1	3.6	Yes
9189	MLS000699016	C11H12N2O3S3	316.408	7 / 1	2.0	Yes
9190	MLS000703412	C11H12N2O3S3	316.408	7 / 1	2.0	Yes
11299	MLS000713029	C18H23N3O3	329.4	5 / 1	3.1	Yes
15983	(5Z)-5-(4-hydroxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one	C15H15NO3S2	321.409	5 / 1	3.0	Yes
17078	SMR000118449	C16H32N4O6	376.454	8 / 2	-2.6	Yes
17220	2-(4-chlorophenyl)-N-(2-methoxy-5-nitrophenyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide	C23H16ClN3O5	449.847	5 / 1	4.1	Yes
17813	SMR000129696	C16H10F3N5OS3	441.465	11 / 2	4.7	No
17847	MLS000689985	C23H17NO4	371.392	4 / 1	4.2	Yes
18010	MLS000028153	C15H19N3	241.338	2 / 1	2.4	Yes
19242	Nicotinamide_dinucleotide	C21H27N7O14P2	663.43	18 / 7	-6.0	No
21239	708241-96-7	C17H18BrN3O2	376.254	4 / 1	3.7	Yes
27232	2-methoxy-N-[2-(3-methyl-4-nitro-5-isoxazolyl)vinyl]aniline	C13H13N3O4	275.264	6 / 1	2.6	Yes
27237	CHEMBL224730	C23H32N9O5+	514.567	7 / 5	-2.5	No
28299	(2E,5E)-2,5-bis(2,4-dimethoxybenzylidene)cyclopentanone	C23H24O5	380.44	5 / 0	4.4	Yes
30573	TCMDC-123502	C18H21Cl2NO	338.272	2 / 2	4.7	Yes
558273	AC1NZ11R	C19H23N3O5S	405.469	7 / 3	2.2	Yes
37855	MLS000714665	C17H19NO4S2	365.462	6 / 1	3.4	Yes
38550	MLS000698167	C22H24IN3O	473.358	2 / 1	N/A	N/A
38832	CHEMBL224655	C21H32N6O4	432.525	5 / 4	-0.4	Yes
41093	MLS000554145	C19H21N3OS	339.457	3 / 1	3.6	Yes
41420	2,3,6-triphenylimidazo[1,2-b][1,2,4]triazine	C23H16N4	348.409	3 / 0	4.7	Yes
41898	AM-1638	C33H35FO4	514.637	5 / 1	7.8	No
42679	MLS001033855	C13H13BrFN3S	342.23	4 / 2	N/A	N/A
43720	MLS001018872	C21H23N3O2	349.434	3 / 2	3.1	Yes
46256	MLS000579119	C18H15ClN2O4	358.778	5 / 1	3.1	Yes
52884	CHEMBL1484167	C26H29BrN2OS	497.495	4 / 1	N/A	N/A
53688	MLS000677316	C17H11N3O5	337.291	6 / 1	2.5	Yes
53990	SMR000043948	C21H16N4O3S	404.444	6 / 1	3.1	Yes
56351	(6E)-5-imino-2-isobutyl-6-[(4-oxo-4H-chromen-3-yl)methylene]-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one	C19H16N4O3S	380.422	6 / 1	3.1	Yes
57263	(2-{[2-(4-Fluorophenyl)-1H-indol-3-yl]thio}ethyl)amine	C16H15FN2S	286.368	3 / 2	3.4	Yes
58883	SMR000105815	C13H11F3N2O2	284.238	7 / 0	2.5	Yes
553552	MeTRH	C17H24N6O4	376.417	5 / 3	-2.3	Yes
61770	MLS000778612	C18H16N2O5S3	436.515	8 / 2	3.8	Yes
62495	1-Pentyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline	C20H20N4	316.408	3 / 0	4.4	Yes
63943	2-(2-hydroxy-5-methylbenzoyl)pyrido[1,2-a][1,3]benzimidazole-4-carbonitrile	C20H13N3O2	327.343	4 / 1	4.8	Yes
65430	MLS000082525	C15H17N3O4S	335.378	7 / 1	2.1	Yes
72117	MLS000536105	C17H11ClF3N3O3S2	461.858	10 / 2	5.2	No
72810	MLS002157414	C21H19N3O5S	425.459	7 / 1	2.3	Yes
73031	CHEMBL374625	C20H29N5O4	403.483	5 / 3	-0.9	Yes
73032	CHEMBL224715	C20H29N5O4	403.483	5 / 3	-0.9	Yes
75541	AC1O3J72	C17H14N2O3S2	358.43	5 / 1	5.1	No
559646	6-bromo-N'-[(1E)-(2-hydroxy-3-methoxyphenyl)methylene]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide	C17H15BrN4O3	403.236	5 / 2	3.7	Yes
77238	MLS001116411	C22H27ClFN3O2S	451.985	6 / 1	4.6	Yes
77747	MLS001173005	C18H16N2O3	308.337	4 / 1	2.7	Yes
81463	3-(trifluoromethyl)benzo[g]quinoxalin-2-ol	C13H7F3N2O	264.207	5 / 1	3.1	Yes
81984	SMR000078105	C16H12N4OS3	372.479	7 / 2	4.4	Yes
82518	MLS000779148	C16H9N3O4S	339.325	6 / 2	1.5	Yes
85992	BAS 00429920	C22H20N2O4	376.412	5 / 1	3.1	Yes
88679	MLS001166676	C20H20N2O4	352.39	5 / 2	3.0	Yes
89104	MLS000862743	C22H35NO5S	425.584	6 / 0	2.9	Yes
91572	1-tert-butyl-3-methyl-4-[(2-nitrophenyl)thio]-1H-pyrazol-5-yl acetate	C16H19N3O4S	349.405	6 / 0	3.5	Yes
91619	MLS000712878	C19H18N2O5	354.362	5 / 2	2.9	Yes
560151	3-hydroxy-4-((E)-{[(5-methoxy-1-methyl-1H-indol-2-yl)carbonyl]hydrazono}methyl)-2-naphthoic acid	C23H19N3O5	417.421	6 / 3	4.2	Yes
99464	ST041961	C19H19NO2	293.366	3 / 0	2.8	Yes
99911	MLS001100829	C25H26FN3O3	435.499	6 / 1	4.0	Yes
100145	MLS001207297	C17H12N2O4S2	372.413	6 / 3	3.4	Yes
560536	AC1OBEWP	C19H17N3O3	335.363	5 / 1	2.8	Yes
560589	MLS000595131	C23H23N3O4S	437.514	6 / 2	3.7	Yes
108848	2-chloro-6-fluoro-N-[2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]benzamide	C22H17ClFN3O2	409.845	4 / 1	5.7	No
110668	AC1LTR2R	C19H16N2O6S2	432.465	8 / 3	3.4	Yes
113577	CHEMBL223876	C20H29N5O4	403.483	5 / 3	-1.0	Yes
113578	CHEMBL388350	C20H29N5O4	403.483	5 / 3	-1.0	Yes
116081	MLS000586692	C19H16N2O6S	400.405	8 / 2	3.4	Yes
560947	MLS001125585	C16H11BrN2O3	359.179	4 / 2	4.1	Yes
117867	MLS001199446	C17H13FO5S	348.344	6 / 1	3.4	Yes
118613	CHEMBL388812	C20H30N6O4	418.498	5 / 4	-0.9	Yes
118878	MLS000570530	C18H15BrN2O4	403.232	5 / 3	4.0	Yes
119174	N-{4-[1-benzoyl-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide	C25H25N3O5S	479.551	7 / 1	3.3	Yes
119735	N-(2-chlorobenzyl)-N'-(2-methylphenyl)-N-(pyridin-3-ylmethyl)thiourea	C21H20ClN3S	381.922	2 / 1	4.6	Yes
120605	SMR000172341	C19H13F3N2O4S	422.378	9 / 2	3.5	Yes
561081	AC1NSAWC	C18H15N3O3	321.336	5 / 3	1.8	Yes
125320	AC1M3Q9P	C23H23ClN2O3S	442.958	5 / 1	6.2	No
125530	AC1O5PEJ	C22H25ClN2O3	400.903	4 / 1	N/A	N/A
129945	CHEMBL389037	C24H30N6O4	466.542	5 / 3	0.1	Yes
133533	1-(3-methoxyphenyl)-2-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3,4,9-tetrahydro-1H-beta-carboline	C23H24N4O	372.472	3 / 1	3.4	Yes
133599	4-(benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one	C22H14N2O4S	402.424	6 / 1	4.6	Yes
133647	MLS000777053	C21H12N2O4S	388.397	6 / 1	4.4	Yes
134394	SMR000218862	C22H16ClNO4	393.823	5 / 0	4.5	Yes
134459	MLS001138759	C28H30N4O6	518.57	7 / 2	3.4	No
137127	Pyronin Y	C17H19ClN2O	302.802	3 / 0	N/A	N/A
141166	N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide	C19H17N5O	331.379	4 / 2	3.3	Yes
145779	NECA	C12H16N6O4	308.298	8 / 4	-0.7	Yes
147955	MLS000521066	C20H21N3O2	335.407	3 / 1	2.9	Yes
148651	2-methylpropyl 6-(6-bromo(2H-benzo[d]1,3-dioxolan-5-yl))-3,4-dimethyl-2-oxo-1, 3,6-trihydropyrimidine-5-carboxylate	C18H21BrN2O5	425.279	5 / 1	3.0	Yes
151995	MLS000580448	C12H22N2OS	242.381	2 / 1	2.4	Yes
155977	MLS000775763	C21H16F2N2O5S	446.425	9 / 3	4.6	Yes
164810	SMR000062009	C20H18N6O3S	422.463	7 / 3	2.1	Yes
168570	SMR000147498	C22H20ClN3OS2	441.992	5 / 1	6.2	No
170603	4-amino-5-[(4-methoxyphenoxy)methyl]-4H-1,2,4-triazole-3-thiol	C10H12N4O2S	252.292	5 / 2	0.9	Yes
171482	MLS002162744	C21H24N4O2	364.449	4 / 1	2.9	Yes
172774	MLS000418558	C28H35N5O3	489.62	6 / 1	2.4	Yes
174011	SMR000078971	C21H26N2O5S2	450.568	7 / 0	2.6	Yes
174252	3-(2-oxo-2-phenylethyl)quinoxalin-2(1h)-one	C16H12N2O2	264.284	3 / 1	2.2	Yes
177724	CHEMBL389858	C21H31N5O4	417.51	5 / 3	-0.4	Yes
177725	CHEMBL389955	C21H31N5O4	417.51	5 / 3	-0.4	Yes
177917	MLS001215909	C17H17IN2	376.241	1 / 1	N/A	N/A

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