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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	MLS000713029
Molecular formula	C18H23N3O3
IUPAC name	(Z)-2-cyano-N-cyclohexyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enamide
Molecular weight	329.4
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	(Z)-2-cyano-N-cyclohexyl-3-[5-(4-morpholinyl)-2-furanyl]-2-propenamide cid_929419 AKOS000627082 SMR000282796 (Z)-2-cyano-N-cyclohexyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enamide ZINC520049 2-Cyano-N-cyclohexyl-3-(5-morpholin-4-yl-furan-2-yl)-acrylamide HMS2682C14 BAS 01567106 SR-01000314401 (Z)-2-cyano-N-cyclohexyl-3-(5-morpholino-2-furyl)acrylamide CHEMBL1421228 AC1LIDPM BDBM60144 SR-01000314401-1 [ Show all ]
Inchi Key	APSOMBILXZWHQR-OWBHPGMISA-N
Inchi ID	InChI=1S/C18H23N3O3/c19-13-14(18(22)20-15-4-2-1-3-5-15)12-16-6-7-17(24-16)21-8-10-23-11-9-21/h6-7,12,15H,1-5,8-11H2,(H,20,22)/b14-12-
PubChem CID	929419
ChEMBL	CHEMBL1421228
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	4109.5 nM	PubChem BioAssay data set	ChEMBL
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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