●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BindProf is a method for predicting free energy changes (ΔΔG) of protein-protein binding interactions upon mutations of residues at the interface. While BindProf adopts a multi-scale approach using multiple sources of information at different levels of structural resolution, a unique feature of BindProf is the inclusion of an interface structural profile score derived from multiple structure alignments from analogous protein-protein interactions (>> read more about BindProf ...).

NOTE: This server is only for dimeric complexes currently with mutations at ONE SIDE of the interface,
            and both protein chains MUST be indexed from 1.

• potential_terms.csv: scores for each feature for the SKEMPI database of mutations of protein complexes.
• profile_only.csv: final 10-fold cross-validated model constructed using only the structural profiles and sequence dependent terms.
• cbeta.csv: model constructed using the structural profiles, sequence dependent terms, and C-Beta terms.
• all_atom.csv: model constructed with all terms including those requiring a full atom model.

• J R Brender, Y Zhang. Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles, PLoS Comput Biol. 2015 Oct 27;11(10):e1004494 [PDF] [Supplemental Information] .