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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	SMR000105815
Molecular formula	C13H11F3N2O2
IUPAC name	9-methyl-4-(trifluoromethyl)-7,8-dihydro-6H-pyrano[2,3-b][1,8]naphthyridin-2-one
Molecular weight	284.238
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	2.5
Synonyms	DFTKAPQWXBEJOB-UHFFFAOYSA-N 9-methyl-4-(trifluoromethyl)-7,8-dihydro-6H-pyrano[2,3-b][1,8]naphthyridin-2-one BDBM50850 MLS000109880 cid_535721 STL328182 9-Methyl-4-(trifluoromethyl)-6,7,8,9-tetrahydro-2H-pyrano[2,3-b][1,8]naphthyridin-2-one HMS2343O24 AC1LBH9A MolPort-002-557-009 4-(Trifluoromethyl)-8-methyl-5,6,7,8-tetrahydro-2H-1-oxa-8,9-diazaanthracene-2-one CTK7H7319 ZINC4477688 9-Methyl-4-(trifluoromethyl)-6,7,8,9-tetrahydro-2H-pyrano[2,3-b][1,8]naphthyridin-2-one # MCULE-7761146390 AKOS022111467 CHEMBL1479965 6,7,8,9-Tetrahydro-9-methyl-4-trifluoromethyl-2H-pyrano[2,3-b][1,8]naphthyridin-2-one [ Show all ]
Inchi Key	DFTKAPQWXBEJOB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H11F3N2O2/c1-18-4-2-3-7-5-8-9(13(14,15)16)6-10(19)20-12(8)17-11(7)18/h5-6H,2-4H2,1H3
PubChem CID	535721
ChEMBL	CHEMBL1479965
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
470190	Parathyroid hormone/parathyroid hormone-related peptide receptor	Q03431	PTH1R	Homo sapiens (Human)	593
58883	Thyrotropin-releasing hormone receptor	P34981	TRHR	Homo sapiens (Human)	398

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