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| Name | Parathyroid hormone/parathyroid hormone-related peptide receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | PTH1R |
| Synonym | PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR [ Show all ] |
| Disease | N/A |
| Length | 593 |
| Amino acid sequence | MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM |
| UniProt | Q03431 |
| Protein Data Bank | 6fj3, 3h3g, 3c4m |
| GPCR-HGmod model | N/A |
| 3D structure model | This structure is from PDB ID 6fj3. |
| BioLiP | BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683 |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL1793 |
| IUPHAR | N/A |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 462974 |  SMR000082495 | C23H24N4O3 | 404.47 | 4 / 1 | 1.9 | Yes |
| 462975 |  CHEMBL1734241 | C18H19F3N4O4S2 | 476.489 | 10 / 2 | 2.1 | Yes |
| 462976 |  AC1OIWKI | C22H24N4O2S | 408.52 | 3 / 0 | 3.7 | Yes |
| 462977 |  AC1P9W8Y | C22H25ClN2O3 | 400.903 | 4 / 0 | 4.3 | Yes |
| 462978 |  1-(4-Fluoro-3-methyl-benzenesulfonyl)-4-pyridin-2-yl-piperazine | C16H18FN3O2S | 335.397 | 6 / 0 | 2.4 | Yes |
| 462979 |  SMR000115985 | C21H18N4O3S | 406.46 | 5 / 1 | 3.8 | Yes |
| 462980 |  CHEMBL1317251 | C21H20N4O5S2 | 472.534 | 9 / 1 | 3.2 | Yes |
| 462981 |  2-(4-chlorophenyl)-N'-(3-pyridinylmethylene)-4-quinolinecarbohydrazide | C22H15ClN4O | 386.839 | 4 / 1 | 4.3 | Yes |
| 462982 |  CHEMBL1476968 | C24H22N4O3S2 | 478.585 | 8 / 1 | 4.3 | Yes |
| 462983 |  MLS000716936 | C16H14F3N3O5S | 417.359 | 12 / 2 | 3.1 | No |
| 557310 |  MLS001002475 | C18H14N2O2S | 322.382 | 5 / 1 | 3.7 | Yes |
| 462984 |  MLS001359985 | C12H12N4 | 212.256 | 2 / 1 | 1.9 | Yes |
| 462985 |  MLS001116995 | C17H18N2O4S | 346.401 | 5 / 1 | 2.3 | Yes |
| 462986 |  MLS001110184 | C26H31N5O5S | 525.624 | 7 / 2 | 2.0 | No |
| 462987 |  MLS001072616 | C24H25N3O3 | 403.482 | 4 / 1 | 4.1 | Yes |
| 462988 |  AC1MOBES | C25H24N2O6S | 480.535 | 7 / 1 | 2.9 | Yes |
| 462989 |  AC1MMT0U | C14H17NO4 | 263.293 | 4 / 2 | 1.3 | Yes |
| 462990 |  AC1NHO97 | C20H27N5O3S2 | 449.588 | 7 / 1 | 2.1 | Yes |
| 557311 |  AC1NWZI7 | C17H8F4N2OS | 364.318 | 8 / 1 | 4.6 | Yes |
| 462991 |  CHEMBL1532430 | C25H28N4O3 | 432.524 | 6 / 0 | 3.2 | Yes |
| 462992 |  2-[4-(4-fluorophenyl)piperazin-1-yl]-1-(4-methoxyphenyl)ethanone | C19H21FN2O2 | 328.387 | 5 / 0 | 3.3 | Yes |
| 462993 |  CHEMBL1320515 | C18H17ClN2O2S | 360.856 | 3 / 1 | 2.9 | Yes |
| 462994 |  MLS000882561 | C23H22O4 | 362.425 | 4 / 1 | 4.4 | Yes |
| 462995 |  CHEMBL1398111 | C24H23N3O3S | 433.526 | 4 / 2 | 3.9 | Yes |
| 462996 |  9-(4-chlorophenyl)-1,7-dimethyl-1,3,5-trihydro-6H,7H,8H-1,3-diazaperhydroino[1 ,2-h]purine-2,4-dione | C16H16ClN5O2 | 345.787 | 4 / 1 | 2.5 | Yes |
| 462997 |  BAS 09528871 | C15H12Cl2N2O2S | 355.233 | 4 / 1 | 3.6 | Yes |
| 462998 |  MLS000734874 | C23H31N3O3 | 397.519 | 4 / 0 | 3.4 | Yes |
| 462999 |  169132-73-4 | C18H17N3O | 291.354 | 3 / 1 | 3.9 | Yes |
| 463000 |  CHEMBL1559360 | C18H16FNO5S2 | 409.446 | 7 / 0 | 3.6 | Yes |
| 463001 |  5-Nitro-2-p-tolyl-1H-benzoimidazole | C14H11N3O2 | 253.261 | 3 / 1 | 3.8 | Yes |
| 463002 |  SMR000102878 | C18H17ClN2O5S | 408.853 | 7 / 1 | 2.6 | Yes |
| 463003 |  MLS000538897 | C13H15N3O5S | 325.339 | 7 / 1 | 2.2 | Yes |
| 463004 |  AC1MR1M1 | C25H24FN5O2 | 445.498 | 5 / 2 | 2.7 | Yes |
| 463005 |  MLS000882705 | C23H19N3O2 | 369.424 | 4 / 0 | 4.3 | Yes |
| 463006 |  Dibromosalicil | C14H8Br2O4 | 400.022 | 4 / 2 | 4.7 | Yes |
| 463007 |  4-(3,4-Dihydro-1H-isoquinolin-2-yl)-8-methoxy-5H-pyrimido[5,4-b]indole | C20H18N4O | 330.391 | 4 / 1 | 3.7 | Yes |
| 463008 |  1-(4-ethoxyphenyl)-3-(2-fluoro-5-methylphenyl)urea | C16H17FN2O2 | 288.322 | 3 / 2 | 3.3 | Yes |
| 463010 |  1-ethyl-N-[4-(2-furoylamino)phenyl]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide | C23H20N4O4 | 416.437 | 6 / 2 | 2.4 | Yes |
| 463011 |  MLS000388876 | C14H14N2O2S | 274.338 | 5 / 1 | 3.2 | Yes |
| 463013 |  SMR000127857 | C21H18N2O2 | 330.387 | 3 / 1 | 4.5 | Yes |
| 463014 |  AC1PMN3Z | C24H26N4O2 | 402.498 | 3 / 1 | 3.9 | Yes |
| 463015 |  MLS000730737 | C19H16FN5O3S2 | 445.487 | 7 / 1 | 2.8 | Yes |
| 463016 |  3-(Piperidine-1-sulfonyl)-N-thiophen-2-ylmethyl-benzenesulfonamide | C16H20N2O4S3 | 400.526 | 7 / 1 | 2.1 | Yes |
| 463017 |  SMR000024980 | C15H10F7NO | 353.24 | 8 / 0 | 4.2 | Yes |
| 463018 |  N-[2-(4-chlorophenoxy)ethyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | C17H16ClNO4 | 333.768 | 4 / 1 | 3.2 | Yes |
| 463019 |  CHEMBL1472919 | C24H28FN3O3S | 457.564 | 5 / 1 | 4.0 | Yes |
| 463020 |  MLS001141336 | C24H26ClN3O4 | 455.939 | 4 / 1 | 3.4 | Yes |
| 463021 |  MLS001250385 | C18H22N2O5 | 346.383 | 5 / 0 | 3.7 | Yes |
| 463022 |  SR-01000786815 | C18H22N2O5 | 346.383 | 5 / 0 | 3.7 | Yes |
| 463023 |  AC1ORKDO | C15H19N5O2S | 333.41 | 6 / 1 | 1.9 | Yes |
| 463024 |  CHEMBL1440907 | C21H24N6O | 376.464 | 6 / 0 | 2.5 | Yes |
| 463025 |  SMR000047551 | C17H11ClN4O2S | 370.811 | 6 / 0 | 3.8 | Yes |
| 463026 |  SMR000633928 | C25H31N3O5S | 485.599 | 6 / 1 | 2.5 | Yes |
| 463027 |  AC1M8JC3 | C24H26N4O3 | 418.497 | 5 / 0 | 3.7 | Yes |
| 463028 |  SMR000091760 | C20H15N5O3S | 405.432 | 7 / 0 | 2.8 | Yes |
| 463029 |  MLS001236705 | C19H20ClN3O5S2 | 469.955 | 7 / 2 | 3.2 | Yes |
| 463030 |  SMR000207614 | C14H14N2O2 | 242.278 | 3 / 1 | 2.0 | Yes |
| 463031 |  SMR001291542 | C20H15FN2O | 318.351 | 3 / 2 | 3.9 | Yes |
| 463034 |  CHEMBL1437576 | C18H17F3N2O4S | 414.399 | 8 / 1 | 3.4 | Yes |
| 463035 |  MLS000924981 | C20H21NO5S | 387.45 | 6 / 0 | 3.4 | Yes |
| 463036 |  CHEMBL1900596 | C16H17F2N3O3S | 369.387 | 6 / 1 | 1.7 | Yes |
| 463037 |  MLS003509449 | C38H53N5O4 | 643.873 | 5 / 1 | 6.4 | No |
| 463038 |  MLS001116732 | C19H20N4O5S2 | 448.512 | 9 / 1 | 2.5 | Yes |
| 463039 |  MLS001236176 | C18H18FN5O2S | 387.433 | 7 / 1 | 2.5 | Yes |
| 463040 |  AC1NJXT4 | C25H24N2O5S | 464.536 | 6 / 1 | 3.9 | Yes |
| 463045 |  AC1M7D1M | C23H30N2O3 | 382.504 | 4 / 1 | 3.4 | Yes |
| 463046 |  MLS000830224 | C15H8BrF6NO | 412.129 | 7 / 1 | 5.2 | No |
| 463047 |  SMR000600564 | C27H29FN4O4 | 492.551 | 6 / 2 | 2.2 | Yes |
| 463048 |  AC1M8PTL | C12H12N4O2S | 276.314 | 6 / 1 | 1.4 | Yes |
| 463049 |  AC1O5EOP | C16H15ClN2O2 | 302.758 | 2 / 2 | 3.9 | Yes |
| 463050 |  MLS001031372 | C28H29N3O3 | 455.558 | 4 / 0 | 3.6 | Yes |
| 463051 |  MLS003123479 | C17H14ClFN2O | 316.76 | 3 / 2 | 3.7 | Yes |
| 463052 |  AC1N31UB | C20H15NO4 | 333.343 | 5 / 0 | 3.8 | Yes |
| 463053 |  MLS001217849 | C20H27N3OS | 357.516 | 4 / 1 | 4.7 | Yes |
| 463054 |  MLS000773335 | C23H24N4O4S | 452.529 | 7 / 2 | 2.8 | Yes |
| 463055 |  MLS003115968 | C21H20N2O3S3 | 444.582 | 6 / 2 | 4.9 | Yes |
| 463056 |  NSC660296 | C17H16O2 | 252.313 | 2 / 0 | 3.4 | Yes |
| 463057 |  MLS003675053 | C22H27NO5S | 417.52 | 6 / 0 | 3.9 | Yes |
| 463058 |  ASN 10014898 | C17H18ClFN2O2 | 336.791 | 3 / 1 | 2.7 | Yes |
| 463060 |  AC1LWMA3 | C17H19NO3 | 285.343 | 4 / 2 | 3.9 | Yes |
| 463061 |  MLS000718003 | C18H20N4O2 | 324.384 | 4 / 2 | 2.4 | Yes |
| 463064 |  methyl 2-amino-4-(3,4-dichlorophenyl)-6,7-dimethyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate | C18H16Cl2N2O4 | 395.236 | 5 / 1 | 3.3 | Yes |
| 463065 |  CHEMBL1395346 | C24H23FN2O4 | 422.456 | 6 / 2 | 1.7 | Yes |
| 463066 |  AC1NRHIS | C17H11Cl2N3O | 344.195 | 3 / 1 | 4.5 | Yes |
| 463067 |  MLS000389682 | C18H15ClN4O3 | 370.793 | 5 / 1 | 3.6 | Yes |
| 463068 |  MLS000767700 | C20H20N2O4 | 352.39 | 5 / 1 | 2.9 | Yes |
| 463069 |  MLS001073439 | C24H24ClN3O2 | 421.925 | 4 / 1 | 4.2 | Yes |
| 463070 |  MLS001117089 | C16H16N2O4S | 332.374 | 5 / 2 | 2.1 | Yes |
| 463071 |  4-tert-butyl-N-[2-(2-fluorophenoxy)ethyl]benzamide | C19H22FNO2 | 315.388 | 3 / 1 | 4.6 | Yes |
| 463072 |  N'-(1-benzyl-4-piperidinylidene)-3-hydroxy-2-naphthohydrazide | C23H23N3O2 | 373.456 | 4 / 2 | 4.1 | Yes |
| 463073 |  N-(benzylcarbamothioyl)-2-bromobenzamide | C15H13BrN2OS | 349.246 | 2 / 2 | 4.1 | Yes |
| 463074 |  MLS001124200 | C20H28N2O3S | 376.515 | 4 / 0 | 3.2 | Yes |
| 463075 |  MLS003121399 | C23H23N3O3S | 421.515 | 6 / 0 | 5.1 | No |
| 463076 |  ethyl 4-{[(3-nitro-1H-pyrazol-1-yl)acetyl]amino}benzoate | C14H14N4O5 | 318.289 | 6 / 1 | 1.6 | Yes |
| 463077 |  AC1MTPJP | C32H35N3O6S2 | 621.767 | 8 / 2 | 6.1 | No |
| 463078 |  2-(2,5-dimethylphenoxy)-N-(1,3-thiazol-2-yl)propanamide | C14H16N2O2S | 276.354 | 4 / 1 | 3.3 | Yes |
| 463079 |  Enamine_003330 | C15H10N4O | 262.272 | 3 / 0 | 2.1 | Yes |
| 463080 |  CHEMBL1864946 | C23H29N3O3 | 395.503 | 5 / 1 | 3.6 | Yes |
| 463081 |  1-benzyl-5-(4-fluorophenyl)-1H-imidazole-2-thiol | C16H13FN2S | 284.352 | 2 / 1 | 3.2 | Yes |
| 463082 |  1-(2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino}ethyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile | C14H11ClF3N5O2 | 373.72 | 8 / 1 | 1.8 | Yes |
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