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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	N'-(1-benzyl-4-piperidinylidene)-3-hydroxy-2-naphthohydrazide
Molecular formula	C23H23N3O2
IUPAC name	N-[(1-benzylpiperidin-4-ylidene)amino]-3-hydroxynaphthalene-2-carboxamide
Molecular weight	373.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.1
Synonyms	CHEMBL1556917 SMR000231147 MLS000705547 AKOS003288696 N'-(1-benzylpiperidin-4-ylidene)-3-hydroxynaphthalene-2-carbohydrazide HMS2554H15 STK419476 AC1LODX4 MolPort-001-543-492 N-[(1-benzylpiperidin-4-ylidene)amino]-3-hydroxynaphthalene-2-carboxamide MCULE-5983487691 ZINC55009007 AK-968/10953016 [ Show all ]
Inchi Key	ABNVUJNIHXHJML-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23N3O2/c27-22-15-19-9-5-4-8-18(19)14-21(22)23(28)25-24-20-10-12-26(13-11-20)16-17-6-2-1-3-7-17/h1-9,14-15,27H,10-13,16H2,(H,25,28)
PubChem CID	1219007
ChEMBL	CHEMBL1556917
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	112202.0 nM	PubChem BioAssay data set	ChEMBL

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