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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	AC1O3J72
Molecular formula	C17H14N2O3S2
IUPAC name	2-methoxy-4-[(Z)-[4-oxo-3-(phenylazaniumyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenolate
Molecular weight	358.43
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.1
Synonyms	2-methoxy-4-[(Z)-[4-oxo-3-(phenylazaniumyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenolate MolPort-000-742-365 2-methoxy-4-{(Z)-[4-oxo-3-(phenylammonio)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}phenolate AKOS005747459 STL147690
Inchi Key	FDFHGZDQTBXWIJ-GDNBJRDFSA-N
Inchi ID	InChI=1S/C17H14N2O3S2/c1-22-14-9-11(7-8-13(14)20)10-15-16(21)19(17(23)24-15)18-12-5-3-2-4-6-12/h2-10,18,20H,1H3/b15-10-
PubChem CID	6282363
ChEMBL	CHEMBL1605583
IUPHAR	N/A
BindingDB	48081
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	16360.1 nM	PubChem BioAssay data set	ChEMBL

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