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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	SMR000062009
Molecular formula	C20H18N6O3S
IUPAC name	2-amino-N-prop-2-enyl-1-(3-sulfamoylphenyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide
Molecular weight	422.463
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	2.1
Synonyms	381684-11-3 MLS000054177 ZINC2305261 2-amino-N-(prop-2-en-1-yl)-1-(3-sulfamoylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide HMS2279D07 STK534025 AC1LZHQ9 MLS002636824 CHEMBL1505000 SR-01000038242 2-amino-N-prop-2-enyl-1-(3-sulfamoylphenyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide MCULE-4616069131 Z56872917 AKOS001046306 MolPort-000-491-359 HMS1763J01 SR-01000038242-1 [ Show all ]
Inchi Key	KAZMPUPRRWQFPQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N6O3S/c1-2-10-23-20(27)16-17-19(25-15-9-4-3-8-14(15)24-17)26(18(16)21)12-6-5-7-13(11-12)30(22,28)29/h2-9,11H,1,10,21H2,(H,23,27)(H2,22,28,29)
PubChem CID	1923620
ChEMBL	CHEMBL1505000
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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