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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	ST041961
Molecular formula	C19H19NO2
IUPAC name	(E)-3-(4-morpholin-4-ylphenyl)-1-phenylprop-2-en-1-one
Molecular weight	293.366
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.8
Synonyms	MolPort-002-190-199 AB00104697-01 SR-01000231132-1 (2E)-3-(4-morpholin-4-ylphenyl)-1-phenylprop-2-en-1-one HMS2589J07 3-[4-(4-morpholinyl)phenyl]-1-phenyl-2-propen-1-one AC1NT8WQ SMR000268654 CHEMBL1419009 (2E)-3-[4-(4-morpholinyl)phenyl]-1-phenyl-2-propen-1-one MLS000680352 6236-25-5 AKOS005154507 SR-01000231132 DTXSID60417594 ZINC5091501 (E)-3-(4-morpholin-4-ylphenyl)-1-phenylprop-2-en-1-one [ Show all ]
Inchi Key	GLOZWQPXJZJOHF-DHZHZOJOSA-N
Inchi ID	InChI=1S/C19H19NO2/c21-19(17-4-2-1-3-5-17)11-8-16-6-9-18(10-7-16)20-12-14-22-15-13-20/h1-11H,12-15H2/b11-8+
PubChem CID	5349489
ChEMBL	CHEMBL1419009
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	18356.4 nM	PubChem BioAssay data set	ChEMBL
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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