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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	1-Pentyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline
Molecular formula	C20H20N4
IUPAC name	1-pentyl-3-phenylpyrazolo[4,3-b]quinoxaline
Molecular weight	316.408
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.4
Synonyms	MLS000557568 AC1M0PEO STL239633 1-amyl-3-phenyl-pyrazolo[4,3-b]quinoxaline MCULE-6028804238 1-pentyl-3-phenylpyrazolo[4,3-b]quinoxaline AKOS025278382 MolPort-002-622-960 CHEMBL1390056 ZINC2434818 MLS-0087264.0001 848748-67-4 BDBM44475 SMR000148484 cid_2031089 1-pentyl-3-phenyl-pyrazolo[4,3-b]quinoxaline [ Show all ]
Inchi Key	DKOWSOMMUFZILP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H20N4/c1-2-3-9-14-24-20-19(18(23-24)15-10-5-4-6-11-15)21-16-12-7-8-13-17(16)22-20/h4-8,10-13H,2-3,9,14H2,1H3
PubChem CID	2031089
ChEMBL	CHEMBL1390056
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	16360.1 nM	PubChem BioAssay data set	ChEMBL

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