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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	AC1M3Q9P
Molecular formula	C23H23ClN2O3S
IUPAC name	4-[[4-(4-chlorophenyl)-5-ethyl-1,3-thiazol-2-yl]-pentanoylamino]benzoic acid
Molecular weight	442.958
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	6.2
Synonyms	CHEMBL1359246 MLS000693236 ZINC2838821 HMS2684C10 4-[[4-(4-chlorophenyl)-5-ethyl-1,3-thiazol-2-yl](pentanoyl)amino]benzoic acid MolPort-002-257-788 MCULE-1101710283 4-[[4-(4-chlorophenyl)-5-ethyl-1,3-thiazol-2-yl]-pentanoylamino]benzoic acid SMR000299655 [ Show all ]
Inchi Key	HVWLSDCKJPYKLH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23ClN2O3S/c1-3-5-6-20(27)26(18-13-9-16(10-14-18)22(28)29)23-25-21(19(4-2)30-23)15-7-11-17(24)12-8-15/h7-14H,3-6H2,1-2H3,(H,28,29)
PubChem CID	2194734
ChEMBL	CHEMBL1359246
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	32642.7 nM	PubChem BioAssay data set	ChEMBL

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