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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	6-bromo-N'-[(1E)-(2-hydroxy-3-methoxyphenyl)methylene]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
Molecular formula	C17H15BrN4O3
IUPAC name	6-bromo-N-[(E)-(2-hydroxy-3-methoxyphenyl)methylideneamino]-2-methylimidazo[1,2-a]pyridine-3-carboxamide
Molecular weight	403.236
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.7
Synonyms	AC1O9DZ4 CHEMBL3197761 SMR000312864 6-bromo-N'-[(E)-(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide AKOS000438195 MLS000689620 AC1O6R1S MolPort-003-873-748 6-bromo-N'-[(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide [ Show all ]
Inchi Key	FDNICFQJVPCJJP-UFWORHAWSA-N
Inchi ID	InChI=1S/C17H15BrN4O3/c1-10-15(22-9-12(18)6-7-14(22)20-10)17(24)21-19-8-11-4-3-5-13(25-2)16(11)23/h3-9,23H,1-2H3,(H,21,24)/b19-8+
PubChem CID	135472793
ChEMBL	CHEMBL3197761
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	18356.4 nM	PubChem BioAssay data set	ChEMBL

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