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Name | Thyrotropin-releasing hormone receptor |
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Species | Homo sapiens (Human) |
Gene | TRHR |
Synonym | Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor |
Disease | Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders [ Show all ] |
Length | 398 |
Amino acid sequence | MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS |
UniProt | P34981 |
Protein Data Bank | N/A |
GPCR-HGmod model | P34981 |
3D structure model | This predicted structure model is from GPCR-EXP P34981. |
BioLiP | N/A |
Therapeutic Target Database | T77796 |
ChEMBL | CHEMBL1810 |
IUPHAR | 363 |
DrugBank | BE0008659 |
Name | MLS001215909 |
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Molecular formula | C17H17IN2 |
IUPAC name | 5-methyl-3-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole;iodide |
Molecular weight | 376.241 |
Hydrogen bond acceptor | 1 |
Hydrogen bond donor | 1 |
XlogP | None |
Synonyms | MLS-0322574.0001 SMR000544817 CHEMBL1320566 AKOS032399980 MCULE-2339508017 [ Show all ] |
Inchi Key | KTPIWCWTGVSAQW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H16N2.HI/c1-13-3-6-17-16(11-13)15(12-18-17)5-4-14-7-9-19(2)10-8-14;/h3-12H,1-2H3;1H |
PubChem CID | 24761146 |
ChEMBL | CHEMBL1320566 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 18356.4 nM | PubChem BioAssay data set | ChEMBL |
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