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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	2,3,6-triphenylimidazo[1,2-b][1,2,4]triazine
Molecular formula	C23H16N4
IUPAC name	2,3,6-triphenylimidazo[1,2-b][1,2,4]triazine
Molecular weight	348.409
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.7
Synonyms	EU-0052526 NCGC00173361-01 VU0104423-5 AC1LDXEF BRD-K40958593-001-11-6 HMS2383I09 SR-01000529940 CHEMBL1531566 MLS000573689 STK762903 F3095-4760 Oprea1_857052 Z56763797 AKOS000669464 CBDivE_011551 MCULE-8860005695 SR-01000529940-1 10243-70-6 cid_702952 MolPort-000-653-512 TimTec1_005944 A2272/0095747 HMS1550O04 SMR000184539 ZINC85434 BDBM44521 MLS-0096782.0001 ST4055952 2,3,6-triphenylimidazo[1,2-b]1,2,4-triazine [ Show all ]
Inchi Key	CGLIDRNLWKCDLU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H16N4/c1-4-10-17(11-5-1)20-16-27-23(24-20)25-21(18-12-6-2-7-13-18)22(26-27)19-14-8-3-9-15-19/h1-16H
PubChem CID	702952
ChEMBL	CHEMBL1531566
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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