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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	Pyronin Y
Molecular formula	C17H19ClN2O
IUPAC name	[6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium;chloride
Molecular weight	302.802
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	None
Synonyms	AI3-52862 C11179 HY-D0971 Methyl pyronin NSC10454 Pyronin Y, for NA electrophoresis SBB080721 UNII-W659G165T1 [7-(dimethylamino)dibenzo[b,e]oxin-3-yl]dimethylamine, chloride 3,6-bis(dimethylamino)-xanthylium chloride 6-(dimethylamino)-N,N-dimethylxanthen-3-iminium chloride AMMONIUM, (6-(DIMETHYLAMINO)-3H-XANTEN-3-YLIDENE)DIMETHYL-, CHLORIDE CHEMBL1486690 LS-17700 MolPort-001-795-077 Pyronin J Pyronin Yellow SMR001224393 Xanthylium, 3,6-bis(dimethylamino)-, chloride (1:1) AC1L1NZ1 BBC/419 EINECS 202-147-8 Methanaminium, N-(6-(dimethylamino)-3H-xanthen-3-ylidene)-N-methyl-, chloride NSC 10454 Pyronin Y, certified by the Biological Stain Commission, Dye content 50 % Pyronine Y Tetramethyl pyronin [6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium chloride 20195-95-3 AKOS005267240 CHEBI:8682 I14-50418 MFCD00011725 Pyronin Pyronin Y, pure, certified SCHEMBL1263862 W659G165T1 3,6-Bis(dimethylamino)xanthylium chloride 61260-70-6 AN-24231 CS-7516 M869 N-(6-(Dimethylamino-3H-Xanthen-3-Ylidene)-N-Methyl-Methanaminium Chloride Pyronine ST080679 [6-(dimethylamino)xanthen-3-ylidene]-dimethyl-ammonium 115624-92-5 AC1Q1SCY C.I. 45005 HMS3020H13 Methanaminium, N-(6-(dimethylamino)-3H-xanthen-3-ylidene)-N-methyl-, chloride (9CI) NSC-10454 Pyronin Y, for microscopy (Bot., Fl., Hist.) Pyronine ZH tetramethyldiaminoxanthylium chloride [6-(dimethylamino)xanthen-3-ylidene]dimethylamine, chloride 3,6-bis(dimethylamino)-10$l^{4}-xanthen-10-ylium chloride AKOS015916487 KS-0000471K MLS001359873 Pyronin G Pyronin Y, pure, high purity biological stain Schultz No. 853 Xanthylium, 3,6-bis(dimethylamino)-, chloride 6-(dimethylamino)-N,N-dimethyl-3H-xanthen-3-iminium chloride 92-32-0 ARONIS24263 DTXSID8059051 MCULE-6105528808 N-[6-(dimethylamino)-3H-xanthen-3-ylidene]-N-methylmethanaminium chloride Pyronin Y (C.I. 45005) Pyronine G ST51006753 [6-(dimethylamino)xanthen-3-ylidene]-dimethyl-ammonium chloride 167382-93-6 [ Show all ]
Inchi Key	INCIMLINXXICKS-UHFFFAOYSA-M
Inchi ID	InChI=1S/C17H19N2O.ClH/c1-18(2)14-7-5-12-9-13-6-8-15(19(3)4)11-17(13)20-16(12)10-14;/h5-11H,1-4H3;1H/q+1;/p-1
PubChem CID	7085
ChEMBL	CHEMBL1486690
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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