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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	MLS000557918
Molecular formula	C20H24N4O2
IUPAC name	N-[7-methyl-1-(2-methylpropyl)pyrazolo[3,4-b]quinolin-3-yl]oxolane-2-carboxamide
Molecular weight	352.438
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	MolPort-002-623-999 BRD-A75867812-001-08-0 cid_4209814 N-[7-methyl-1-(2-methylpropyl)-3-pyrazolo[3,4-b]quinolinyl]-2-oxolanecarboxamide 713089-04-4 STK569603 AKOS032390502 N-(1-isobutyl-7-methyl-pyrazolo[3,4-b]quinolin-3-yl)tetrahydrofuran-2-carboxamide HMS2410N04 N-[7-methyl-1-(2-methylpropyl)pyrazolo[3,4-b]quinolin-3-yl]oxolane-2-carboxamide AC1N64WO MolPort-000-756-411 Tetrahydro-furan-2-carboxylic acid (1-isobutyl-7-methyl-1H-pyrazolo[3,4-b]quinolin-3-yl)-amide BDBM68792 CHEMBL1302024 N-[(3E)-7-methyl-1-(2-methylpropyl)-1,2-dihydro-3H-pyrazolo[3,4-b]quinolin-3-ylidene]tetrahydrofuran-2-carboxamide MCULE-8173820049 SMR000148634 AKOS005495000 [ Show all ]
Inchi Key	AHTCKTSEEJTFQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24N4O2/c1-12(2)11-24-19-15(10-14-7-6-13(3)9-16(14)21-19)18(23-24)22-20(25)17-5-4-8-26-17/h6-7,9-10,12,17H,4-5,8,11H2,1-3H3,(H,22,23,25)
PubChem CID	4209814
ChEMBL	CHEMBL1302024
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	6513.1 nM	PubChem BioAssay data set	ChEMBL

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