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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	MeTRH
Molecular formula	C17H24N6O4
IUPAC name	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-5-oxopyrrolidine-2-carboxamide
Molecular weight	376.417
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-2.3
Synonyms	GTPL2137 [3H]Me-thyrotropin-releasing hormone AC1NSKDH His(1-methyl)-TRH [3H]pGlu-His(1(tau)-methyl)-ProNH2 (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-5-oxopyrrolidine-2-carboxamide D0YS1H pGlu-His(1(t)-methyl)-ProNH2 GTPL2141 [3H]MeTRH CTK1A8669 L-Prolinamide, 1-methyl-5-oxo-L-prolyl-L-histidyl- (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-5-oxopyrrolidine-2-carboxamide DTXSID50415524 pGlu-His(1(tau)-methyl)-ProNH2 38983-06-1 His(1-methyl)-thyrotropin-releasing hormone [3H]pGlu-His(1(t)-methyl)-ProNH2 D0YA7R [ Show all ]
Inchi Key	DJLHRAHTTSWYAW-AVGNSLFASA-N
Inchi ID	InChI=1S/C17H24N6O4/c1-22-13(4-5-14(22)24)16(26)21-11(7-10-8-19-9-20-10)17(27)23-6-2-3-12(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,19,20)(H,21,26)/t11-,12-,13-/m0/s1
PubChem CID	5311291
ChEMBL	N/A
IUPHAR	2137, 2141
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553551	Thyrotropin-releasing hormone receptor	Q01717	Trhr	Rattus norvegicus (Rat)	412
553552	Thyrotropin-releasing hormone receptor	P34981	TRHR	Homo sapiens (Human)	398

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