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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	SMR000218862
Molecular formula	C22H16ClNO4
IUPAC name	(2-oxo-3-quinolin-2-ylchromen-7-yl) 4-chlorobutanoate
Molecular weight	393.823
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.5
Synonyms	cid_1835281 ZINC17354100 4-chlorobutanoic acid [2-oxo-3-(2-quinolinyl)-1-benzopyran-7-yl] ester AC1LXR9L MLS000591251 (2-oxidanylidene-3-quinolin-2-yl-chromen-7-yl) 4-chloranylbutanoate ST51027699 2-oxo-3-(quinolin-2-yl)-2H-chromen-7-yl 4-chlorobutanoate 4-chlorobutyric acid [2-keto-3-(2-quinolyl)chromen-7-yl] ester HMS2589L05 AKOS005544762 MolPort-000-832-443 (2-oxo-3-quinolin-2-ylchromen-7-yl) 4-chlorobutanoate CHEMBL1480809 STK609849 4-Chloro-butyric acid 2-oxo-3-quinolin-2-yl-2H-chromen-7-yl ester 796880-44-9 MCULE-9382273157 BDBM90156 2-oxo-3-(2-quinolyl)chromen-7-yl 4-chlorobutanoate [ Show all ]
Inchi Key	IJAVBJVEKJZMOK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H16ClNO4/c23-11-3-6-21(25)27-16-9-7-15-12-17(22(26)28-20(15)13-16)19-10-8-14-4-1-2-5-18(14)24-19/h1-2,4-5,7-10,12-13H,3,6,11H2
PubChem CID	1835281
ChEMBL	CHEMBL1480809
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	16360.1 nM	PubChem BioAssay data set	ChEMBL

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