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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	MLS001033855
Molecular formula	C13H13BrFN3S
IUPAC name	N-(3,4-dihydro-2H-pyrrol-5-yl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine;hydrobromide
Molecular weight	342.23
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	None
Synonyms	SMR000385723 CHEMBL1351045
Inchi Key	CIGSMHNBASYCPI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H12FN3S.BrH/c14-10-5-3-9(4-6-10)11-8-18-13(16-11)17-12-2-1-7-15-12;/h3-6,8H,1-2,7H2,(H,15,16,17);1H
PubChem CID	16196826
ChEMBL	CHEMBL1351045
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	2909.3 nM	PubChem BioAssay data set	ChEMBL

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