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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	3-(2-oxo-2-phenylethyl)quinoxalin-2(1h)-one
Molecular formula	C16H12N2O2
IUPAC name	3-phenacyl-1H-quinoxalin-2-one
Molecular weight	264.284
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.2
Synonyms	AC1Q79BO EN300-11094 Oprea1_645088 3-(2-oxo-2-phenylethyl)-1,2-dihydroquinoxalin-2-one 3-Phenacyl-2(1H)-quinoxalinone MolPort-002-467-565 2(1H)-Quinoxalinone,3-(2-oxo-2-phenylethyl)- AC1Q5H0Z CTK4E9145 NSC10182 2-phenacyl-3-hydroxyquinoxaline AKOS000118600 HMS2706K13 SMR000372782 3-phenacyl-2-quinoxalone CHEMBL1544695 NSC-10182 2-(3-HYDROXY-2-QUINOXALINYL)-1-PHENYLETHANONE AC1Q69IN DTXSID00278808 NSC99097 22298-77-7 3-phenacyl-1H-quinoxalin-2-one BDBM43198 MLS001003120 ZINC18087573 AC1L5C93 cid_223034 NSC-99097 2-(3-hydroxyquinoxalin-2-yl)-1-phenylethan-1-one [ Show all ]
Inchi Key	KOQHYOQMYFQWPR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H12N2O2/c19-15(11-6-2-1-3-7-11)10-14-16(20)18-13-9-5-4-8-12(13)17-14/h1-9H,10H2,(H,18,20)
PubChem CID	223034
ChEMBL	CHEMBL1544695
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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