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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AM-1638
Molecular formula	C33H35FO4
IUPAC name	(3S)-3-cyclopropyl-3-[3-[[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Molecular weight	514.637
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	7.8
Synonyms	SB11246 BDBM50392861 (S)-3-Cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoic acid CS-0007046 AKOS025290929 SCHEMBL2495289 1142214-62-7 HY-13467 ZINC95576548 CHEMBL2152070 [ Show all ]
Inchi Key	CHEANNSDVJOIBS-MHZLTWQESA-N
Inchi ID	InChI=1S/C33H35FO4/c1-33(2)15-5-8-30(33)28-16-21(9-13-26(28)29-18-24(37-3)12-14-31(29)34)20-38-25-7-4-6-23(17-25)27(19-32(35)36)22-10-11-22/h4,6-9,12-14,16-18,22,27H,5,10-11,15,19-20H2,1-3H3,(H,35,36)/t27-/m0/s1
PubChem CID	57706778
ChEMBL	CHEMBL2152070
IUPHAR	N/A
BindingDB	50392861
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
41900	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
41899	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
41897	Free fatty acid receptor 1	O14842	FFAR1	Homo sapiens (Human)	300
41902	Gastrin/cholecystokinin type B receptor	P32239	CCKBR	Homo sapiens (Human)	447
41903	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
41901	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
41898	Thyrotropin-releasing hormone receptor	P34981	TRHR	Homo sapiens (Human)	398

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