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| Name | Gastrin/cholecystokinin type B receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | CCKBR |
| Synonym | CCK-B receptor CCK-B receptor {ECO:0000303|PubMed:8415658} CCK-B/gastrin receptor CCK-BR gastrin/cholecystokinin type B receptor [ Show all ] |
| Disease | Diagnostic imaging Duodenal ulcers Gastroesophageal reflux disease Gastrointestinal disease Intestine cancer [ Show all ] |
| Length | 447 |
| Amino acid sequence | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG |
| UniProt | P32239 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P32239 |
| 3D structure model | This predicted structure model is from GPCR-EXP P32239. |
| BioLiP | N/A |
| Therapeutic Target Database | T05849 |
| ChEMBL | CHEMBL298 |
| IUPHAR | 77 |
| DrugBank | BE0001158 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 74 |  CHEMBL504861 | C34H31FN4O4 | 578.644 | 7 / 1 | 6.3 | No |
| 119 |  CHEMBL343158 | C21H18FN3OS | 379.453 | 5 / 2 | 3.8 | Yes |
| 629 |  CHEMBL37699 | C25H20BrN3O2 | 474.358 | 3 / 1 | 5.1 | No |
| 1039 |  CHEMBL217353 | C19H19BrN4O3S2 | 495.41 | 7 / 0 | 3.5 | Yes |
| 1092 |  CHEMBL140749 | C22H22FN3OS | 395.496 | 5 / 2 | 3.7 | Yes |
| 1320 |  CHEMBL389713 | C31H36N6O5 | 572.666 | 7 / 2 | 4.6 | No |
| 1848 |  CHEMBL336690 | C22H26FN3O2 | 383.467 | 5 / 1 | 4.4 | Yes |
| 1870 |  CHEMBL261682 | C20H19BrN4O3S | 475.361 | 6 / 1 | 3.3 | Yes |
| 1995 |  CHEMBL293026 | C44H52N8O10 | 852.946 | 10 / 10 | 3.7 | No |
| 2215 |  CHEMBL411271 | C53H71N9O15S | 1106.26 | 15 / 10 | 4.5 | No |
| 3216 |  CHEMBL354049 | C33H40N4O5 | 572.706 | 6 / 5 | 4.8 | No |
| 3219 |  CHEMBL83942 | C33H40N4O5 | 576.722 | 6 / 5 | 4.8 | No |
| 4025 |  CHEMBL2110202 | C25H29N9O2 | 487.568 | 7 / 4 | 3.2 | Yes |
| 4227 |  CHEMBL570521 | C21H15Cl3N4O3S2 | 541.846 | 7 / 2 | 6.0 | No |
| 4724 |  CHEMBL292856 | C28H36N8O3 | 532.649 | 6 / 4 | 3.5 | No |
| 5016 |  CHEMBL432266 | C33H32FN9O3 | 621.677 | 8 / 3 | 3.8 | No |
| 5562 |  CHEMBL140495 | C24H22FN3O2 | 403.457 | 5 / 2 | 4.4 | Yes |
| 5650 |  CCK-A Agonist 34 | C35H32FN5O4 | 605.67 | 6 / 1 | 5.7 | No |
| 5798 |  CHEMBL283914 | C35H38Cl2N4O6 | 681.611 | 6 / 4 | 5.9 | No |
| 5839 |  BDBM50321606 | C80H98N18O14 | 1535.78 | 17 / 18 | 2.2 | No |
| 5992 |  CCK-A Agonist 20 | C37H36N4O4 | 600.719 | 4 / 1 | 6.4 | No |
| 6099 |  CHEMBL566177 | C25H18BrCl2FN4O5S | 656.304 | 9 / 2 | 5.5 | No |
| 6448 |  CHEMBL404967 | C30H34N6O6 | 574.638 | 7 / 2 | 4.1 | No |
| 6450 |  CHEMBL565298 | C22H15BrClFN4O5S2 | 613.857 | 10 / 3 | 5.1 | No |
| 6547 |  CHEMBL424076 | C25H20N4O2 | 408.461 | 3 / 2 | 3.7 | Yes |
| 7057 |  CHEMBL357983 | C30H34N4O6 | 546.624 | 6 / 3 | 3.8 | No |
| 7272 |  CHEMBL3144540 | C45H57N7O10 | 855.99 | 10 / 8 | 3.8 | No |
| 7273 |  CHEMBL60731 | C45H57N7O10 | 855.99 | 10 / 8 | 3.8 | No |
| 7549 |  CHEMBL97133 | C34H42N4O3 | 554.735 | 3 / 3 | 5.7 | No |
| 7586 |  CHEMBL3144554 | C45H55N7O10 | 853.974 | 10 / 8 | 4.0 | No |
| 442013 |  CHEMBL3351053 | C39H49N5O7 | 699.849 | 8 / 5 | 2.8 | No |
| 442014 |  CHEMBL3351062 | C39H49N5O7 | 699.849 | 8 / 5 | 2.8 | No |
| 7675 |  CHEMBL294954 | C39H49N5O7 | 699.849 | 8 / 5 | 2.8 | No |
| 7677 |  CHEMBL49259 | C39H49N5O7 | 699.849 | 8 / 5 | 2.8 | No |
| 7723 |  CHEMBL319196 | C28H33N3O4 | 475.589 | 4 / 2 | 4.2 | Yes |
| 8481 |  CHEMBL339515 | C29H30Cl2N4O3 | 553.484 | 3 / 3 | 5.5 | No |
| 8525 |  CHEMBL217715 | C19H19ClN4O4S2 | 466.955 | 8 / 1 | 3.8 | Yes |
| 8550 |  CHEMBL127397 | C30H34N4O3 | 498.627 | 3 / 3 | 4.6 | Yes |
| 8734 |  CHEMBL443550 | C25H21Cl2N3O2 | 466.362 | 3 / 1 | 5.2 | No |
| 8944 |  CHEMBL137208 | C25H24N4O2 | 412.493 | 3 / 2 | 3.8 | Yes |
| 9326 |  CHEMBL336749 | C23H19FN4O2 | 402.429 | 4 / 2 | 3.0 | Yes |
| 9867 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10009 |  CHEMBL102867 | C27H26Cl2N4O3 | 525.43 | 3 / 2 | 5.2 | No |
| 10621 |  Cholecystokinin-9 | C55H74N14O17S3 | 1299.46 | 21 / 16 | -4.1 | No |
| 10682 |  CHEMBL413654 | C97H126N20O32S | 2116.24 | 34 / 27 | -3.9 | No |
| 11491 |  CHEMBL3144564 | C44H53N7O13S | 920.004 | 13 / 9 | 3.1 | No |
| 11508 |  CHEMBL135988 | C21H24N4O2 | 364.449 | 3 / 2 | 2.4 | Yes |
| 11647 |  CHEMBL2111654 | C31H34N4O5 | 542.636 | 5 / 2 | 3.5 | No |
| 12712 |  CHEMBL1907850 | C23H17BrFN3O2 | 466.31 | 4 / 1 | 3.6 | Yes |
| 12911 |  CHEMBL293490 | C33H39N5O6S | 633.764 | 6 / 4 | 3.8 | No |
| 13176 |  CHEMBL399918 | C18H19BrN2O5S2 | 487.383 | 7 / 1 | 3.9 | Yes |
| 13254 |  CHEMBL101803 | C26H33N3O3 | 435.568 | 3 / 2 | 4.5 | Yes |
| 13595 |  CHEMBL355319 | C27H29N3O4 | 459.546 | 4 / 2 | 4.6 | Yes |
| 13884 |  CHEMBL380907 | C32H41N5O3 | 543.712 | 5 / 1 | 5.9 | No |
| 14005 |  CHEMBL3144543 | C44H55N7O11 | 857.962 | 11 / 10 | 3.2 | No |
| 14008 |  CHEMBL62184 | C44H55N7O11 | 857.962 | 11 / 10 | 3.2 | No |
| 14379 |  CHEMBL342614 | C24H19ClN4O4 | 462.89 | 5 / 3 | 3.7 | Yes |
| 14453 |  CHEMBL70883 | C28H23FN4O4 | 498.514 | 6 / 2 | 4.5 | Yes |
| 14927 |  CHEMBL287564 | C34H48Cl2N4O6 | 679.68 | 6 / 4 | 5.9 | No |
| 14928 |  CHEMBL34101 | C34H48Cl2N4O6 | 679.68 | 6 / 4 | 5.9 | No |
| 15268 |  CHEMBL332595 | C28H30N4O3 | 470.573 | 3 / 2 | 5.1 | No |
| 16085 |  CHEMBL502398 | C56H67N9O12 | 1058.2 | 14 / 8 | 3.2 | No |
| 16381 |  CHEMBL22630 | C21H16FN3O4 | 393.374 | 6 / 2 | 2.5 | Yes |
| 17106 |  CHEMBL264273 | C61H83N11O17S | 1274.45 | 17 / 13 | 4.1 | No |
| 17109 |  CHEMBL1907839 | C23H18IN3O2 | 495.32 | 3 / 1 | 4.4 | Yes |
| 17243 |  CHEMBL1907842 | C24H18F3N3O2 | 437.422 | 6 / 1 | 4.1 | Yes |
| 17246 |  CHEMBL2092865 | C24H18F3N3O2 | 437.422 | 6 / 1 | 4.1 | Yes |
| 18216 |  CHEMBL285739 | C33H40Cl2N4O6 | 659.605 | 6 / 3 | 4.7 | No |
| 18376 |  CHEMBL105527 | C30H33N3O3 | 483.612 | 3 / 2 | 5.0 | Yes |
| 18618 |  CHEMBL390276 | C32H32N4O5 | 552.631 | 6 / 2 | 5.4 | No |
| 18780 |  CHEMBL118610 | C35H46N6O7 | 662.788 | 7 / 6 | 3.2 | No |
| 19253 |  CHEMBL321800 | C31H35N3O4 | 513.638 | 4 / 2 | 4.5 | No |
| 19869 |  CHEMBL32301 | C25H30N4O4 | 450.539 | 4 / 4 | 3.0 | Yes |
| 20007 |  CHEMBL306958 | C23H19FN4O2 | 402.429 | 4 / 2 | 3.5 | Yes |
| 20214 |  CHEMBL53234 | C23H17ClN6O | 428.88 | 4 / 2 | 3.7 | Yes |
| 20913 |  CHEMBL328422 | C44H56N8O9 | 840.979 | 9 / 9 | 4.1 | No |
| 20916 |  CHEMBL319311 | C44H56N8O9 | 840.979 | 9 / 9 | 4.1 | No |
| 21012 |  CHEMBL177799 | C35H44N6O7 | 660.772 | 7 / 7 | 2.8 | No |
| 21017 |  CHEMBL2371222 | C35H44N6O7 | 660.772 | 7 / 7 | 2.8 | No |
| 21019 |  CHEMBL2371223 | C35H44N6O7 | 660.772 | 7 / 7 | 2.8 | No |
| 21281 |  CHEMBL277661 | C22H18N2O4 | 374.396 | 4 / 2 | 3.4 | Yes |
| 21283 |  CHEMBL22918 | C22H18N2O4 | 374.396 | 4 / 2 | 3.4 | Yes |
| 21370 |  CHEMBL350853 | C23H27N5O2 | 405.502 | 3 / 2 | 2.7 | Yes |
| 21838 |  131449-37-1 | C45H55N7O10 | 853.974 | 10 / 8 | 3.9 | No |
| 21842 |  CHEMBL433640 | C45H55N7O10 | 853.974 | 10 / 8 | 3.9 | No |
| 21997 |  CHEMBL3143025 | C42H51N9O11 | 857.922 | 11 / 9 | 3.2 | No |
| 21998 |  CHEMBL7423 | C42H51N9O11 | 857.922 | 11 / 9 | 3.2 | No |
| 22012 |  CHEMBL34335 | C24H29N3O4 | 423.513 | 4 / 2 | 3.7 | Yes |
| 522121 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522189 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22212 |  CHEMBL410905 | C20H20BrN3O3S2 | 494.422 | 6 / 1 | 4.9 | Yes |
| 22599 |  CHEMBL301261 | C31H34N4O5 | 542.636 | 5 / 4 | 4.1 | No |
| 22616 |  CHEMBL420459 | C32H42N4O3 | 530.713 | 3 / 2 | 7.4 | No |
| 22643 |  CHEMBL74170 | C27H27N3O2 | 425.532 | 3 / 2 | 5.9 | No |
| 23690 |  CHEMBL303386 | C30H32N4O4 | 512.61 | 5 / 2 | 4.8 | No |
| 23829 |  CHEMBL115656 | C31H38N4O2 | 498.671 | 3 / 2 | 6.7 | No |
| 23831 |  CHEMBL115456 | C31H38N4O2 | 498.671 | 3 / 2 | 6.7 | No |
| 442610 |  Talnetant | C25H22N2O2 | 382.463 | 3 / 2 | 5.7 | No |
| 24397 |  CHEMBL30592 | C30H35Cl2N3O5 | 588.526 | 5 / 3 | 5.8 | No |
| 24398 |  CHEMBL30481 | C30H35Cl2N3O5 | 588.526 | 5 / 3 | 5.8 | No |
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