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| Name | D(1A) dopamine receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | DRD1 |
| Synonym | D1 receptor D1A DADR Gpcr15 dopamine D1 receptor [ Show all ] |
| Disease | Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder [ Show all ] |
| Length | 446 |
| Amino acid sequence | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT |
| UniProt | P21728 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P21728 |
| 3D structure model | This predicted structure model is from GPCR-EXP P21728. |
| BioLiP | N/A |
| Therapeutic Target Database | T22118 |
| ChEMBL | CHEMBL2056 |
| IUPHAR | 214 |
| DrugBank | BE0000020 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 459235 |  CHEMBL3697590 | C19H17F2N3O3 | 373.36 | 7 / 1 | 3.7 | Yes |
| 92 |  Eticlopride | C17H25ClN2O3 | 340.848 | 4 / 2 | 3.1 | Yes |
| 97 |  AC1O8PYY | C17H25ClN2O3 | 340.848 | 4 / 2 | 3.1 | Yes |
| 227 |  CHEMBL379286 | C33H29Cl2N5O3 | 614.527 | 6 / 1 | 6.2 | No |
| 378 |  CHEMBL321223 | C38H30BrN3O6S | 736.637 | 8 / 5 | 6.7 | No |
| 535918 |  CHEMBL3983937 | C22H27N5OS | 409.552 | 6 / 0 | 3.3 | Yes |
| 658 |  CHEMBL1710306 | C16H15ClN5O6PS | 471.809 | 11 / 3 | 0.5 | No |
| 748 |  MLS000084280 | C15H17N3O | 255.321 | 2 / 1 | 1.8 | Yes |
| 1025 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 1063 |  CHEMBL2420770 | C15H17FN2S | 276.373 | 4 / 0 | 3.2 | Yes |
| 521489 |  CHEMBL3781035 | C25H33NO4 | 411.542 | 5 / 1 | 5.2 | No |
| 1654 |  CHEMBL210461 | C31H35Cl2N3O | 536.541 | 3 / 1 | 7.3 | No |
| 1783 |  ciproxifan | C16H18N2O2 | 270.332 | 3 / 1 | 2.5 | Yes |
| 441745 |  CHEMBL329566 | C20H23NO | 293.41 | 2 / 0 | 3.6 | Yes |
| 1923 |  CHEMBL371352 | C20H23NO | 293.41 | 2 / 0 | 3.6 | Yes |
| 1962 |  CHEMBL484356 | C23H24BrNO2 | 426.354 | 3 / 4 | N/A | N/A |
| 2001 |  CHEMBL574700 | C36H46N6O3 | 610.803 | 8 / 2 | 5.4 | No |
| 2289 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 2405 |  CHEMBL425069 | C27H28ClN5O3 | 506.003 | 6 / 1 | 4.3 | No |
| 3123 |  L-Cysteinesulfinic acid | C3H7NO4S | 153.152 | 6 / 3 | -4.2 | Yes |
| 3133 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 3383 |  SCHEMBL6820733 | C21H23F3N4S | 420.498 | 6 / 2 | 4.3 | Yes |
| 3461 |  CHEMBL201177 | C21H24N2 | 304.437 | 1 / 1 | 4.6 | Yes |
| 3597 |  2-Phenylcyclopropanamine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 3741 |  tetrahydropalmatine | C21H25NO4 | 355.434 | 5 / 0 | 3.2 | Yes |
| 3746 |  D-Tetrahydropalmatine | C21H25NO4 | 355.434 | 5 / 0 | 3.2 | Yes |
| 3827 |  cid_655014 | C16H12N4OS2 | 340.419 | 6 / 2 | 3.3 | Yes |
| 4000 |  MLS000118160 | C20H18N4O3 | 362.389 | 6 / 1 | 3.2 | Yes |
| 521581 |  CHEMBL3797876 | C17H21NO5 | 319.357 | 6 / 4 | 1.6 | Yes |
| 521589 |  CHEMBL3799593 | C17H21NO5 | 319.357 | 6 / 4 | 1.6 | Yes |
| 4664 |  120-78-5 | C14H8N2S4 | 332.472 | 6 / 0 | 5.6 | No |
| 4828 |  CHEMBL232206 | C29H26F3N5S | 533.617 | 9 / 0 | 6.2 | No |
| 4966 |  7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid | C22H40O2 | 336.56 | 2 / 1 | 8.5 | No |
| 4992 |  CHEMBL2203622 | C18H22N2O2 | 298.386 | 3 / 0 | 3.8 | Yes |
| 5365 |  CHEMBL396560 | C21H24N2O | 320.436 | 2 / 1 | 4.3 | Yes |
| 5379 |  Indolo[2,3-b]quinoxalin-6-yl-acetic acid ethyl ester | C18H15N3O2 | 305.337 | 4 / 0 | 3.2 | Yes |
| 5667 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 5774 |  paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 6140 |  CHEMBL3215641 | C19H24Cl2N2O2S | 415.373 | 5 / 5 | N/A | N/A |
| 6221 |  CHEMBL213444 | C28H25ClN6O | 496.999 | 5 / 1 | 4.6 | Yes |
| 6434 |  SMR000073240 | C13H13N3O2S | 275.326 | 6 / 1 | 3.0 | Yes |
| 6660 |  CHEMBL598516 | C23H25ClN2O2 | 396.915 | 3 / 2 | 4.1 | Yes |
| 463730 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 6998 |  Mevastatin | C23H34O5 | 390.52 | 5 / 1 | 3.9 | Yes |
| 536138 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7605 |  FENRETINIDE | C26H33NO2 | 391.555 | 2 / 2 | 7.3 | No |
| 459286 |  Tavapadon | C19H16F3N3O3 | 391.35 | 7 / 1 | 3.3 | Yes |
| 8056 |  CHEMBL3671296 | C20H16N6O | 356.389 | 5 / 1 | 3.2 | Yes |
| 442038 |  CHEMBL3344465 | C21H25NO2S | 355.496 | 4 / 1 | 4.6 | Yes |
| 8201 |  BW-723C86 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
| 8226 |  ethyl 3-amino-5-phenylthiophene-2-carboxylate | C13H13NO2S | 247.312 | 4 / 1 | 3.7 | Yes |
| 8458 |  CHEMBL598105 | C26H23ClN2O | 414.933 | 3 / 1 | 5.8 | No |
| 459296 |  CHEMBL3697593 | C20H21N3O3 | 351.406 | 5 / 1 | 3.1 | Yes |
| 9707 |  MLS000102793 | C20H15N3O4S2 | 425.477 | 8 / 1 | 3.5 | Yes |
| 547997 |  CHEMBL3982215 | C21H25NO5 | 371.433 | 6 / 2 | 2.4 | Yes |
| 9863 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10171 |  CHEMBL194206 | C23H30FN5O2 | 427.524 | 6 / 1 | 2.7 | Yes |
| 10445 |  SB 204070 hydrochloride | C19H27ClN2O4 | 382.885 | 6 / 1 | 3.5 | Yes |
| 10713 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10873 |  CHEMBL3289645 | C19H22F3N3O | 365.4 | 7 / 0 | 4.0 | Yes |
| 548012 |  CHEMBL3976659 | C21H24BrNO4 | 434.33 | 5 / 2 | 4.2 | Yes |
| 11018 |  CHEMBL201086 | C11H12O2 | 176.215 | 2 / 0 | 2.2 | Yes |
| 11054 |  tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
| 11128 |  MLS000106678 | C11H12N2OS | 220.29 | 4 / 0 | 3.1 | Yes |
| 11722 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 459324 |  CHEMBL3697620 | C20H19F2N3O3 | 387.387 | 6 / 1 | 3.4 | Yes |
| 11906 |  MLS000062775 | C17H16N2O2 | 280.327 | 2 / 2 | 3.2 | Yes |
| 12018 |  CHEMBL517244 | C35H44N2O | 508.75 | 3 / 0 | 7.8 | No |
| 12212 |  CHEMBL216047 | C31H33Cl2N5O | 562.539 | 4 / 1 | 7.4 | No |
| 12278 |  CHEMBL213668 | C26H24ClN5O3 | 489.96 | 6 / 1 | 4.2 | Yes |
| 12457 |  CHEMBL3671303 | C18H14ClN5O | 351.794 | 5 / 1 | 3.7 | Yes |
| 12626 |  CHEMBL568031 | C15H13ClN2O | 272.732 | 2 / 2 | 3.0 | Yes |
| 12836 |  CHEMBL1940408 | C20H24ClFN2 | 346.874 | 3 / 0 | 5.3 | No |
| 13551 |  N-Methylserotonin | C11H14N2O | 190.246 | 2 / 3 | 0.7 | Yes |
| 13621 |  ADTN | C10H13NO2 | 179.219 | 3 / 3 | 1.4 | Yes |
| 13636 |  CHEMBL26998 | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 13689 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 13815 |  CHEMBL380330 | C19H23NO | 281.399 | 2 / 0 | 4.1 | Yes |
| 13865 |  daphnetin | C9H6O4 | 178.143 | 4 / 2 | 1.2 | Yes |
| 14127 |  CHEMBL212950 | C28H29Cl2N5O | 522.474 | 4 / 1 | 6.3 | No |
| 14165 |  cid_652353 | C14H14N4OS | 286.353 | 5 / 2 | 2.8 | Yes |
| 14172 |  N-butyl-3,4-dichloro-N-ethylbenzamide | C13H17Cl2NO | 274.185 | 1 / 0 | 5.0 | Yes |
| 14570 |  CHEMBL282136 | C17H18N2O2 | 282.343 | 4 / 3 | 1.8 | Yes |
| 14666 |  TCMDC-124336 | C16H14N4S2 | 326.436 | 5 / 0 | 4.1 | Yes |
| 14721 |  CHEMBL213201 | C26H23ClN6O | 470.961 | 5 / 1 | 4.1 | Yes |
| 14911 |  NCGC00016051-01 | C13H8N4O3 | 268.232 | 7 / 4 | 0.2 | Yes |
| 14916 |  Allopregnanolone | C21H34O2 | 318.501 | 2 / 1 | 4.9 | Yes |
| 15026 |  CHEMBL1806814 | C22H26N2O2 | 350.462 | 3 / 1 | 4.3 | Yes |
| 15028 |  CHEMBL1806813 | C22H26N2O2 | 350.462 | 3 / 1 | 4.3 | Yes |
| 15086 |  disulfiram | C10H20N2S4 | 296.524 | 4 / 0 | 3.9 | Yes |
| 15460 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 15580 |  CHEMBL577267 | C12H13ClN2O | 236.699 | 2 / 2 | 1.8 | Yes |
| 15730 |  CHEMBL303993 | C16H16ClNO | 273.76 | 2 / 1 | 3.8 | Yes |
| 15732 |  CHEMBL293158 | C16H16ClNO | 273.76 | 2 / 1 | 3.8 | Yes |
| 15906 |  CHEMBL3671285 | C20H15N5O | 341.374 | 5 / 1 | 3.6 | Yes |
| 15977 |  MLS000099123 | C17H15NO5 | 313.309 | 5 / 1 | 2.9 | Yes |
| 442278 |  CHEMBL3321789 | C22H25ClFNO2 | 389.895 | 4 / 1 | 4.8 | Yes |
| 521947 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 16386 |  CHEMBL597702 | C31H29ClF2N2O | 519.033 | 5 / 1 | 7.3 | No |
| 16399 |  CHEMBL234829 | C27H27F3N2OS | 484.581 | 7 / 0 | 6.5 | No |
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