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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	L-Cysteinesulfinic acid
Molecular formula	C3H7NO4S
IUPAC name	(2R)-2-amino-3-sulfinopropanoic acid
Molecular weight	153.152
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-4.2
Synonyms	BPBio1_001212 Cysteine sulfinate GTPL5447 Lopac0_000263 NCGC00260948-01 Tocris-0216 3-sulphino-L-alanine ADVPTQAUNPRNPO-REOHCLBHSA-N CCG-204358 D0S4NR L-CSA NCGC00024500-01 SCHEMBL189097 UNII-UZY4HYK4ZX component ADVPTQAUNPRNPO-REOHCLBHSA-N (2R)-2-amino-3-sulfinopropanoic acid Biomol-NT_000190 CHEMBL1160508 FF909059-FA51-40A0-8973-9E4ECFB8C92A NCGC00024500-04 SR-01000597398 3-Sulfino-L-alanine 56X032NVQL C 4418 Cysteine sulfinic acid HMS3260F08 LP00263 S-cysteinesulfinic acid Tox21_500263 AKOS006280503 CHEBI:16345 DB02153 L-Cysteine sulfinic acid NCGC00024500-02 SR-01000075758 ZINC19419008 1115-65-7 bmse000706 CTK0H5128 FT-0633338 L-Cysteinesulphinic Acid NCGC00024500-05 SR-01000597398-1 3-sulfinoalanine AC1LU7QV C00606 Cysteinesulfinic acid L-Alanine, 3-sulfino- MolPort-006-112-940 S-sulfinocysteine UNII-56X032NVQL B6225 EU-0100263 L-cysteine sulphinic acid NCGC00024500-03 SR-01000075758-1 3-sulfinato-L-alaninate [ Show all ]
Inchi Key	ADVPTQAUNPRNPO-REOHCLBHSA-N
Inchi ID	InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/t2-/m0/s1
PubChem CID	1549098
ChEMBL	CHEMBL1160508
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	18356.4 nM	PubChem BioAssay data set	ChEMBL

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