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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	Indolo[2,3-b]quinoxalin-6-yl-acetic acid ethyl ester
Molecular formula	C18H15N3O2
IUPAC name	ethyl 2-indolo[3,2-b]quinoxalin-6-ylacetate
Molecular weight	305.337
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.2
Synonyms	AC1LDB67 cid_645300 MCULE-1164662736 ST50332400 BDBM48903 ethyl 2-indolo[3,2-b]quinoxalin-6-ylethanoate Oprea1_306545 25681-03-2 CHEMBL1539939 HMS608P02 SR-01000467024 AKOS000528190 ethyl 2-indolo[2,3-b]quinoxalin-5-ylacetate MLS000035955 STL301016 2-(6-indolo[3,2-b]quinoxalinyl)acetic acid ethyl ester CCG-109349 ethyl 6H-indolo[2,3-b]quinoxalin-6-ylacetate Oprea1_645071 ChemDiv1_007724 SR-01000467024-1 BAS 00033013 ethyl 2-indolo[3,2-b]quinoxalin-6-ylacetate MolPort-000-678-275 ZINC358278 2-indolo[3,2-b]quinoxalin-6-ylacetic acid ethyl ester HMS2369P19 SMR000001010 [ Show all ]
Inchi Key	AHABQJDNQDDOMO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15N3O2/c1-2-23-16(22)11-21-15-10-6-3-7-12(15)17-18(21)20-14-9-5-4-8-13(14)19-17/h3-10H,2,11H2,1H3
PubChem CID	645300
ChEMBL	CHEMBL1539939
IUPHAR	N/A
BindingDB	48903
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.00538 nM	N/A	BindingDB

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