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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	MLS000062775
Molecular formula	C17H16N2O2
IUPAC name	2-benzamido-N-prop-2-enylbenzamide
Molecular weight	280.327
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.2
Synonyms	STK709640 AC1M3OYD CHEMBL1325020 N-allyl-2-benzamido-benzamide 2-benzamido-N-prop-2-enyl-benzamide J3.563.813J SR-01000265894 AKOS003448122 MolPort-002-091-361 ZINC2838023 cid_2194118 Oprea1_782665 2-benzamido-N-prop-2-enylbenzamide MCULE-8813234372 SR-01000265894-1 A2262/0095270 BDBM49082 N-allyl-2-(benzoylamino)benzamide HMS2471P03 SMR000073616 2-[(phenylcarbonyl)amino]-N-(prop-2-en-1-yl)benzamide [ Show all ]
Inchi Key	AQMJKODHLTZTGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H16N2O2/c1-2-12-18-17(21)14-10-6-7-11-15(14)19-16(20)13-8-4-3-5-9-13/h2-11H,1,12H2,(H,18,21)(H,19,20)
PubChem CID	2194118
ChEMBL	N/A
IUPHAR	N/A
BindingDB	49082
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.0389 nM	N/A	BindingDB

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