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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	ethyl 3-amino-5-phenylthiophene-2-carboxylate
Molecular formula	C13H13NO2S
IUPAC name	ethyl 3-amino-5-phenylthiophene-2-carboxylate
Molecular weight	247.312
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	ALBB-021927 DB-014775 FT-0682291 MolPort-001-920-735 3-Amino-5-phenylthiophene-2-carboxylic acid ethyl ester A10580 BDBM49079 ethyl 3-amino-5-phenyl-2-thiophenecarboxylate I04-1347 SMR000069098 1838AF ACMC-20edqs cid_838333 ethyl3-amino-5-phenylthiophene-2-carboxylate MCULE-3893537141 Z56910429 3-amino-5-phenyl-2-thiophenecarboxylic acid ethyl ester ALFMTFUIVUKCCM-UHFFFAOYSA-N DTXSID70356940 HMS1416N21 SBB077820 AC1LHI8E CHEBI:121667 IFLab1_001715 STL387984 2-Thiophenecarboxylic acid, 3-amino-5-phenyl-, ethyl ester AKOS000121976 CTK5G0717 F0412-0168 MLS000058832 ZINC365893 3-Amino-5-phenyl-thiophene-2-carboxylic acid ethyl ester 88534-50-3 BAS 00281165 EN300-05019 HMS2416I08 SCHEMBL1882680 AC1Q330W CHEMBL1371383 ethyl 3-azanyl-5-phenyl-thiophene-2-carboxylate L-5350 TR-027825 2-Thiophenecarboxylicacid, 3-amino-5-phenyl-, ethyl ester [ Show all ]
Inchi Key	ALFMTFUIVUKCCM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H13NO2S/c1-2-16-13(15)12-10(14)8-11(17-12)9-6-4-3-5-7-9/h3-8H,2,14H2,1H3
PubChem CID	838333
ChEMBL	N/A
IUPHAR	N/A
BindingDB	49079
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.00428 nM	N/A	BindingDB

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