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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	tetrahydropalmatine
Molecular formula	C21H25NO4
IUPAC name	(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Molecular weight	355.434
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.2
Synonyms	6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (S)- AC1Q569Q Berbine, 2,3,9,10-tetramethoxy- CS-8092 Gindarine l-Tetrahydropalmatine NCGC00346591-01 (-)-S-Tetrahydropalmatine SC-96279 (S)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline V0216 2506-20-9 (hydrochloride) 483T147 6H-Dibenzo[a,g]quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- AKOS000277105 Caseanine Hyndarin LS-61256 Q-100022 (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine (S)-isomer of tetrahydropalmatine AC-8007 AX8039153 CHEMBL487182 FT-0674470 InChI=1/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s N-Demethyl-O,O'-dimethylsteponine (-)-Corydalis Rotundium (13aS)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine UNII-3X69CO5I79 2,3,9,10-tetramethoxy-13aalpha-berbine 6H-dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- AEQDJSLRWYMAQI-KRWDZBQOSA-N Berbine, 2,3,9,10-tetramethoxy- (8CI) CTK8G0672 HMS3656M19 Levo-thp (TN) NSC36363 (-)-Tetrahydropalmatine SCHEMBL230850 (S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline ZINC19535049 3X69CO5I79 5,8,13,13a(S)-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine 84-38-8 AN-8428 CHEBI:16563 DB12093 Hyndarine MolPort-000-881-202 (+-)-tetrahydropalmatine Q-100371 (13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline Tetrahydropalmatine (6CI) (S)-Tetrahydropalmatine 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy- AC1L2HTA BDBM50424077 corydalis B gindarin KB-211027 N1727 (-)-Corydalis B s2437 (S)-(-)-tetrahydropalmatine UNII-78F8583LNQ component AEQDJSLRWYMAQI-KRWDZBQOSA-N 2-(2,3-Dimethoxy-benzyl)-1-ethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 6h-dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-,(13as)- AJ-73939 C02890 D01FFA HY-N0096 LS-61253 O,O-Dimethyl-N-demethyl-cyclanoline (-)-Tetrahydropalmatine, >=98% (HPLC) SW219613-1 (S)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine 483-14-7 5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine AC-16039 AS-17459 EBD2156704 I07-0251 N-Demethyl-O,O'-dimethylcyclanoline (-)-2,3,9,10-Tetramethoxyberbine Rotundine (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline tetrahydropalmitine 13a-alpha-Berbine, 2,3,9,10-tetramethoxy- [ Show all ]
Inchi Key	AEQDJSLRWYMAQI-KRWDZBQOSA-N
Inchi ID	InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
PubChem CID	72301
ChEMBL	CHEMBL487182
IUPHAR	N/A
BindingDB	50424077
DrugBank	DB12093
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
3743	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
3740	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
536014	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
3741	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
3742	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443

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