You can:
| Name | Alpha-1A adrenergic receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADRA1A |
| Synonym | alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c [ Show all ] |
| Disease | Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma [ Show all ] |
| Length | 466 |
| Amino acid sequence | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV |
| UniProt | P35348 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P35348 |
| 3D structure model | This predicted structure model is from GPCR-EXP P35348. |
| BioLiP | N/A |
| Therapeutic Target Database | T92609 |
| ChEMBL | CHEMBL229 |
| IUPHAR | 22 |
| DrugBank | BE0000501 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 64 |  CHEMBL309518 | C24H27N3O5S2 | 501.616 | 7 / 0 | 3.5 | No |
| 78 |  CHEMBL287791 | C28H32F3N3O2 | 499.578 | 6 / 1 | 3.9 | Yes |
| 553247 |  diazepam | C16H13ClN2O | 284.743 | 2 / 0 | 3.0 | Yes |
| 547909 |  CHEMBL3937911 | C21H26ClFN2O4S | 456.957 | 7 / 1 | 4.0 | Yes |
| 909 |  CHEMBL342126 | C34H34F4N4O4 | 638.664 | 9 / 2 | 6.1 | No |
| 1293 |  CHEMBL91956 | C35H38N4O5 | 594.712 | 7 / 2 | 5.8 | No |
| 1935 |  CHEMBL93843 | C29H29F3N6O2 | 550.586 | 8 / 1 | 2.5 | No |
| 2011 |  CHEMBL90421 | C27H31F3N4O2 | 500.566 | 6 / 2 | 3.6 | No |
| 2014 |  CHEMBL328268 | C27H31F3N4O2 | 500.566 | 6 / 2 | 3.6 | No |
| 2079 |  RS-513815 | C25H23N5O2 | 425.492 | 5 / 1 | 3.6 | Yes |
| 2080 |  SCHEMBL6802950 | C25H23N5O2 | 425.492 | 5 / 1 | 3.6 | Yes |
| 2273 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 3043 |  CHEMBL1255085 | C23H25NO5 | 395.455 | 6 / 3 | 3.9 | Yes |
| 3124 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 441849 |  CHEMBL3342860 | C27H32F3N3O4 | 519.565 | 9 / 0 | 3.9 | No |
| 536014 |  tetrahydropalmatine | C21H25NO4 | 355.434 | 5 / 0 | 3.2 | Yes |
| 4499 |  CID 44417700 | C24H26ClNO4 | 427.925 | 5 / 1 | N/A | N/A |
| 4504 |  CHEMBL215151 | C24H26ClNO4 | 427.925 | 5 / 2 | N/A | N/A |
| 5059 |  BDBM50068818 | C32H39N5O6 | 589.693 | 8 / 2 | 2.9 | No |
| 547957 |  CHEMBL3983235 | C23H24N2O | 344.458 | 2 / 1 | 4.3 | Yes |
| 5532 |  Rac-3,8,11-Tribromonantenine | C20H18Br3NO4 | 576.079 | 5 / 0 | 5.3 | No |
| 5605 |  Rac-3-Bromonantenine | C20H20BrNO4 | 418.287 | 5 / 0 | 3.9 | Yes |
| 5687 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 5745 |  AHOUBRCZNHFOSL-UHFFFAOYSA-N | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 555504 |  paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 6455 |  CHEMBL1767144 | C22H23N3O3 | 377.444 | 5 / 1 | 0.6 | Yes |
| 6470 |  CHEMBL466425 | C26H28F3N5O2 | 499.538 | 8 / 0 | 2.8 | Yes |
| 463721 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 7237 |  CHEMBL1796042 | C25H30N4O5 | 466.538 | 7 / 0 | 2.7 | Yes |
| 7712 |  CHEMBL453654 | C25H29N3O3 | 419.525 | 5 / 0 | 4.0 | Yes |
| 442021 |  CHEMBL3342852 | C19H28N2O3S | 364.504 | 6 / 0 | 2.5 | Yes |
| 8052 |  CHEMBL163247 | C22H19Cl2N3O2 | 428.313 | 4 / 0 | 4.0 | Yes |
| 547982 |  CHEMBL3984336 | C21H22ClNO4 | 387.86 | 5 / 0 | N/A | N/A |
| 521701 |  CHEMBL3754496 | C16H19FN2 | 258.34 | 2 / 1 | 2.9 | Yes |
| 8643 |  CHEMBL55629 | C22H27F3N4O3 | 452.478 | 8 / 1 | 2.9 | Yes |
| 536200 |  CHEMBL27021 | C19H24N2O | 296.414 | 3 / 0 | 3.8 | Yes |
| 8779 |  CHEMBL220515 | C24H26ClN5O2 | 451.955 | 5 / 1 | 3.6 | Yes |
| 8785 |  CHEMBL1223747 | C24H27F3N4 | 428.503 | 7 / 1 | 5.7 | No |
| 9194 |  CHEMBL201461 | C30H34F3N5O5S | 633.687 | 11 / 1 | 2.7 | No |
| 9859 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10047 |  Abanoquil | C22H25N3O4 | 395.459 | 7 / 1 | 3.4 | Yes |
| 10267 |  CHEMBL145587 | C30H38F2N4O3 | 540.656 | 8 / 0 | 4.3 | No |
| 10737 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10781 |  CHEMBL1242445 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 10789 |  CHEMBL1242444 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 442146 |  CHEMBL1946783 | C31H34N2O6 | 530.621 | 8 / 2 | N/A | No |
| 11355 |  CHEMBL18303 | C16H21N5 | 283.379 | 3 / 2 | 1.6 | Yes |
| 11527 |  3-MPPI | C23H25N5O3 | 419.485 | 5 / 2 | 2.7 | Yes |
| 521785 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 12631 |  CHEMBL62033 | C24H24N4O3 | 416.481 | 5 / 1 | 2.5 | Yes |
| 12637 |  CHEMBL98168 | C25H25NO2 | 371.48 | 3 / 0 | 5.4 | No |
| 12809 |  CHEMBL145894 | C36H40F2N4O4 | 630.737 | 7 / 2 | 6.6 | No |
| 548028 |  CHEMBL3972911 | C24H28N2O3 | 392.499 | 4 / 1 | 4.3 | Yes |
| 13270 |  Rac-2-(Butyloxy)Isodomesticine | C23H27NO4 | 381.472 | 5 / 0 | 4.5 | Yes |
| 13392 |  CHEMBL97859 | C15H21N3O2 | 275.352 | 4 / 2 | 2.7 | Yes |
| 13662 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 14039 |  CHEMBL326837 | C15H19N3O2 | 273.336 | 3 / 1 | 1.8 | Yes |
| 521874 |  CHEMBL3758368 | C26H32N2O2 | 404.554 | 4 / 0 | 5.8 | No |
| 548047 |  CHEMBL3925977 | C31H40N4O3 | 516.686 | 7 / 1 | 2.9 | No |
| 14685 |  CHEMBL302882 | C21H19Br3N4O | 583.122 | 3 / 4 | 4.6 | No |
| 14849 |  CHEMBL1223799 | C25H29FN4 | 404.533 | 5 / 1 | 5.2 | No |
| 14906 |  CHEMBL193620 | C21H26F3N3O2 | 409.453 | 7 / 0 | 3.1 | Yes |
| 15297 |  CHEMBL70095 | C33H38N4O7 | 602.688 | 9 / 2 | 3.5 | No |
| 15326 |  CHEMBL271913 | C27H37ClN4O3 | 501.068 | 5 / 2 | 5.3 | No |
| 15477 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 15792 |  CHEMBL142718 | C28H33F2N7O4 | 569.614 | 8 / 4 | 1.9 | No |
| 521930 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 16118 |  CHEMBL1767165 | C40H52N4O3 | 636.881 | 6 / 0 | 7.6 | No |
| 16534 |  CHEMBL18256 | C14H17N5 | 255.325 | 3 / 2 | 0.7 | Yes |
| 16883 |  Glemanserin | C20H25NO | 295.426 | 2 / 1 | 3.8 | Yes |
| 16924 |  CHEMBL53675 | C21H26F4N4O3 | 458.458 | 9 / 1 | 3.2 | Yes |
| 17200 |  CHEMBL142383 | C30H35N5O8 | 593.637 | 9 / 2 | 3.4 | No |
| 17450 |  SCHEMBL1276324 | C24H26F2N4O2 | 440.495 | 7 / 2 | 4.3 | Yes |
| 17578 |  CHEMBL327931 | C30H35ClN4O5 | 567.083 | 7 / 2 | 5.1 | No |
| 17876 |  CHEMBL267336 | C26H29F4N3O5S | 571.588 | 12 / 1 | 4.0 | No |
| 17882 |  Bmy-7378 | C22H31N3O3 | 385.508 | 5 / 0 | 2.8 | Yes |
| 18334 |  CHEMBL2234452 | C20H25NO5 | 359.422 | 6 / 1 | 2.6 | Yes |
| 18688 |  SK&F-106686 | C14H16ClNS | 265.799 | 2 / 0 | 4.3 | Yes |
| 19138 |  CHEMBL1255003 | C25H29NO3 | 391.511 | 4 / 1 | 5.3 | No |
| 19340 |  CHEMBL432192 | C15H22N4O | 274.368 | 3 / 3 | 2.1 | Yes |
| 536471 |  CHEMBL3957222 | C28H28N2O3 | 440.543 | 4 / 1 | 4.9 | Yes |
| 19683 |  CHEMBL604656 | C12H17N5O5 | 311.298 | 9 / 5 | -1.1 | Yes |
| 19853 |  CHEMBL521096 | C24H28FN5O2 | 437.519 | 7 / 2 | 3.9 | Yes |
| 20049 |  CHEMBL72768 | C11H14FN3S | 239.312 | 4 / 2 | 1.5 | Yes |
| 20172 |  imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
| 21597 |  CHEMBL14213 | C26H28N4O3S | 476.595 | 6 / 0 | 4.1 | Yes |
| 21830 |  BDBM50081825 | C38H46N6O4 | 650.824 | 7 / 3 | 4.3 | No |
| 21899 |  CHEMBL150161 | C20H21ClFNO2 | 361.841 | 4 / 1 | 2.9 | Yes |
| 22205 |  CHEMBL501404 | C15H12FN3O | 269.279 | 4 / 0 | 1.9 | Yes |
| 22423 |  CHEMBL75808 | C24H34N6O2 | 438.576 | 7 / 1 | 1.8 | Yes |
| 22956 |  CHEMBL382972 | C26H31NO5 | 437.536 | 6 / 1 | 4.9 | Yes |
| 23069 |  CHEMBL327712 | C36H39Cl2N3O3 | 632.626 | 5 / 2 | 7.5 | No |
| 23423 |  BDBM50090015 | C27H28F3N5O2 | 511.549 | 7 / 2 | 3.2 | No |
| 23440 |  CHEMBL41677 | C32H38N2O3 | 498.667 | 4 / 1 | 5.8 | No |
| 442606 |  CHEMBL3342872 | C23H31N3O5S2 | 493.637 | 9 / 0 | 2.7 | Yes |
| 24428 |  Nortopsentin A | C19H12Br2N4 | 456.141 | 1 / 3 | 5.0 | Yes |
| 24520 |  1,4-Dihydro-2,6-dimethyl-4-(4-nitrophenyl)-5-[[[3-[4-phenyl-4-(methoxycarbonyl)piperidine-1-yl]propyl]amino]carbonyl]pyridine-3-carboxylic acid 2-cyanoethyl ester | C34H39N5O7 | 629.714 | 10 / 2 | 4.7 | No |
| 25051 |  CHEMBL42231 | C27H31NO3 | 417.549 | 4 / 1 | 5.5 | No |
| 25059 |  CHEMBL81486 | C24H28ClN5O2 | 453.971 | 6 / 1 | 3.9 | Yes |
| 553388 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
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