You can:
| Name | 5-hydroxytryptamine receptor 1A |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HTR1A |
| Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
| Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
| Length | 422 |
| Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
| UniProt | P08908 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P08908 |
| 3D structure model | This predicted structure model is from GPCR-EXP P08908. |
| BioLiP | N/A |
| Therapeutic Target Database | T78709 |
| ChEMBL | CHEMBL214 |
| IUPHAR | 1 |
| DrugBank | BE0000291 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 37 |  MLS000077136 | C12H11N3O6 | 293.235 | 8 / 1 | -0.1 | Yes |
| 557309 |  3-(5-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phenyl)piperazin-1-yl)pentyl)-1H-indole-5-carbonitrile | C29H29F2N5O | 501.582 | 6 / 1 | 5.1 | No |
| 91 |  Eticlopride | C17H25ClN2O3 | 340.848 | 4 / 2 | 3.1 | Yes |
| 98 |  AC1O8PYY | C17H25ClN2O3 | 340.848 | 4 / 2 | 3.1 | Yes |
| 172 |  CHEMBL2111779 | C24H25N3O2 | 387.483 | 4 / 1 | 3.8 | Yes |
| 175 |  CHEMBL119800 | C24H25N3O2 | 387.483 | 4 / 1 | 3.8 | Yes |
| 376 |  MLS000080863 | C14H20N2O3S | 296.385 | 4 / 3 | 2.3 | Yes |
| 411 |  CHEMBL2205042 | C17H21ClN2OS | 336.878 | 4 / 2 | N/A | N/A |
| 486 |  CHEMBL54125 | C22H21FN4 | 360.436 | 4 / 0 | 4.7 | Yes |
| 734 |  CHEMBL49950 | C22H33N5O3 | 415.538 | 7 / 1 | 1.8 | Yes |
| 521459 |  CHEMBL3818128 | C19H23ClFN | 319.848 | 2 / 1 | N/A | N/A |
| 877 |  CHEMBL598037 | C20H21NO2 | 307.393 | 3 / 1 | 3.6 | Yes |
| 879 |  MLS000068755 | C22H18ClN5O | 403.87 | 4 / 1 | 4.7 | Yes |
| 1121 |  CHEMBL2205048 | C17H20N2OS | 300.42 | 4 / 1 | 3.4 | Yes |
| 1195 |  SMR000092791 | C21H16BrN3O3 | 438.281 | 5 / 1 | 4.6 | Yes |
| 553253 |  7-Hydroxy Risperidone | C23H27FN4O3 | 426.492 | 7 / 1 | 1.7 | Yes |
| 1307 |  CHEMBL135890 | C21H24N2O2S | 368.495 | 5 / 2 | 3.7 | Yes |
| 1327 |  CHEMBL109839 | C21H34N2O | 330.516 | 2 / 2 | 5.6 | No |
| 1476 |  4365 CT | C14H20N2O | 232.327 | 2 / 1 | 2.7 | Yes |
| 1491 |  CHEMBL413777 | C23H31NO2 | 353.506 | 3 / 1 | 5.7 | No |
| 1633 |  SCHEMBL6114888 | C25H30BrNO5 | 504.421 | 6 / 2 | 3.8 | No |
| 1658 |  CHEMBL210461 | C31H35Cl2N3O | 536.541 | 3 / 1 | 7.3 | No |
| 1697 |  CHEMBL470849 | C25H28N4O2 | 416.525 | 5 / 1 | 3.8 | Yes |
| 1740 |  CHEMBL3264371 | C21H21F2N5O | 397.43 | 7 / 1 | 2.6 | Yes |
| 1752 |  CHEMBL89448 | C16H24N4O2 | 304.394 | 4 / 3 | 1.4 | Yes |
| 1867 |  CHEMBL53662 | C23H23FN4O | 390.462 | 5 / 0 | 4.7 | Yes |
| 1969 |  Rutaecarpine | C18H13N3O | 287.322 | 2 / 1 | 3.0 | Yes |
| 1982 |  MLS000086795 | C24H28ClN5O4 | 485.969 | 6 / 2 | 2.0 | Yes |
| 1999 |  CHEMBL574700 | C36H46N6O3 | 610.803 | 8 / 2 | 5.4 | No |
| 2046 |  CHEMBL252818 | C24H28N4OS | 420.575 | 5 / 1 | 4.1 | Yes |
| 2249 |  CHEMBL288244 | C23H22Cl2FN3OS | 478.407 | 5 / 1 | 4.8 | Yes |
| 2268 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 2915 |  CHEMBL446459 | C14H19F2N3O | 283.323 | 4 / 2 | 2.6 | Yes |
| 2979 |  CHEMBL317532 | C26H28FNO4 | 437.511 | 6 / 1 | 4.9 | Yes |
| 3042 |  CHEMBL1255085 | C23H25NO5 | 395.455 | 6 / 3 | 3.9 | Yes |
| 3110 |  CHEMBL1794795 | C21H28N2O6 | 404.463 | 7 / 2 | N/A | N/A |
| 521532 |  CHEMBL3818805 | C24H27ClN4O | 422.957 | 2 / 2 | 4.8 | Yes |
| 3136 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 547930 |  CHEMBL3941102 | C28H31F3N4O2 | 512.577 | 8 / 1 | 3.9 | No |
| 3245 |  CHEMBL2442997 | C28H34N4O3 | 474.605 | 6 / 1 | 3.0 | Yes |
| 3330 |  CHEMBL196961 | C29H33N5O2S | 515.676 | 7 / 0 | 4.0 | No |
| 3381 |  CHEMBL135295 | C21H22N2OS | 350.48 | 4 / 0 | 4.1 | Yes |
| 3407 |  CHEMBL1642882 | C18H19ClN4O2S | 390.886 | 5 / 3 | 3.4 | Yes |
| 3600 |  2-Phenylcyclopropanamine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 3644 |  CHEMBL3235731 | C22H34N4O3 | 402.539 | 5 / 1 | 1.8 | Yes |
| 463331 |  CHEMBL3597637 | C25H29ClN4O2 | 452.983 | 5 / 1 | 4.4 | Yes |
| 3689 |  CHEMBL137185 | C21H21ClN2OS | 384.922 | 4 / 0 | 5.0 | Yes |
| 441850 |  CHEMBL3342860 | C27H32F3N3O4 | 519.565 | 9 / 0 | 3.9 | No |
| 3743 |  tetrahydropalmatine | C21H25NO4 | 355.434 | 5 / 0 | 3.2 | Yes |
| 3745 |  D-Tetrahydropalmatine | C21H25NO4 | 355.434 | 5 / 0 | 3.2 | Yes |
| 553260 |  Zalospirone | C24H29N5O2 | 419.529 | 6 / 0 | 1.4 | Yes |
| 3862 |  CHEMBL180119 | C24H31NO | 349.518 | 2 / 0 | 5.5 | No |
| 3888 |  MLS000078794 | C11H13N5O | 231.259 | 5 / 0 | 0.6 | Yes |
| 4099 |  CHEMBL1173578 | C21H16ClN5O2S2 | 469.962 | 7 / 0 | 4.6 | Yes |
| 4289 |  CHEMBL1784932 | C40H56N6O5S | 732.985 | 9 / 1 | 6.5 | No |
| 4306 |  Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1) | C18H22N2O5 | 346.383 | 6 / 4 | N/A | N/A |
| 4562 |  CHEMBL495161 | C25H30N4O2 | 418.541 | 5 / 1 | 3.1 | Yes |
| 4610 |  CHEMBL2159474 | C16H17Cl3N2O3S2 | 455.793 | 6 / 1 | 5.0 | Yes |
| 4772 |  CHEMBL599691 | C24H23FN2O2 | 390.458 | 4 / 1 | 4.7 | Yes |
| 4784 |  CHEMBL268274 | C17H25N3O | 287.407 | 3 / 1 | 3.0 | Yes |
| 4829 |  CHEMBL232206 | C29H26F3N5S | 533.617 | 9 / 0 | 6.2 | No |
| 4964 |  CHEMBL1096802 | C29H33N5O | 467.617 | 6 / 0 | 5.1 | No |
| 5032 |  CHEMBL211135 | C17H17Cl2N5 | 362.258 | 4 / 0 | 3.4 | Yes |
| 5058 |  BDBM50068818 | C32H39N5O6 | 589.693 | 8 / 2 | 2.9 | No |
| 5230 |  SMR000016478 | C22H30N6O4 | 442.52 | 6 / 0 | 1.4 | Yes |
| 5234 |  CHEMBL196744 | C21H24Cl2FN3O | 424.341 | 4 / 1 | 4.9 | Yes |
| 5249 |  SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
| 5439 |  Lesopitron | C15H21ClN6 | 320.825 | 5 / 0 | 1.8 | Yes |
| 5579 |  CHEMBL3144354 | C28H29N3O4S | 503.617 | 6 / 1 | 4.0 | No |
| 5598 |  CHEMBL158749 | C17H23NO | 257.377 | 2 / 1 | 3.7 | Yes |
| 5599 |  CHEMBL158623 | C17H23NO | 257.377 | 2 / 1 | 3.7 | Yes |
| 5689 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 521627 |  CHEMBL3770072 | C28H32N2O | 412.577 | 3 / 0 | 5.0 | Yes |
| 5746 |  AHOUBRCZNHFOSL-UHFFFAOYSA-N | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 5765 |  paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 5881 |  CHEMBL209176 | C21H29N3O2S | 387.542 | 5 / 1 | 3.6 | Yes |
| 6084 |  CHEMBL551964 | C27H25N5O2 | 451.53 | 7 / 0 | 4.3 | Yes |
| 6089 |  CID 10072510 | C27H25N5O2 | 451.53 | 7 / 0 | 4.3 | Yes |
| 6143 |  CHEMBL144128 | C28H38N6O2 | 490.652 | 6 / 4 | 2.3 | Yes |
| 6233 |  CHEMBL604115 | C23H21ClN2O | 376.884 | 2 / 1 | 5.2 | No |
| 521636 |  CHEMBL3758684 | C23H30ClN3O2 | 415.962 | 3 / 2 | 4.9 | Yes |
| 6276 |  CHEMBL76237 | C19H22N2O3S | 358.456 | 4 / 0 | 3.5 | Yes |
| 6436 |  CHEMBL80230 | C24H23N3O3 | 401.466 | 5 / 2 | 3.8 | Yes |
| 6532 |  10-Gingerol | C21H34O4 | 350.499 | 4 / 2 | 5.3 | No |
| 6648 |  CHEMBL1784934 | C40H57N7O5S | 748.0 | 10 / 2 | 5.0 | No |
| 441951 |  CHEMBL3409037 | C30H48N4O2 | 496.74 | 4 / 0 | 4.9 | Yes |
| 6805 |  CHEMBL158210 | C16H21NO | 243.35 | 2 / 2 | 3.4 | Yes |
| 441973 |  CHEMBL3358498 | C24H27FN4O | 406.505 | 5 / 1 | 4.2 | Yes |
| 463706 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 536123 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7051 |  CHEMBL1788190 | C19H27N3O | 313.445 | 2 / 2 | 3.8 | Yes |
| 7052 |  CHEMBL1744036 | C19H27N3O | 313.445 | 2 / 2 | 3.8 | Yes |
| 7087 |  CHEMBL606384 | C25H26N2O2 | 386.495 | 3 / 1 | 4.9 | Yes |
| 7175 |  CHEMBL2159481 | C24H24F2N2O3S | 458.524 | 7 / 1 | 4.6 | Yes |
| 7260 |  CHEMBL54914 | C15H17N5 | 267.336 | 4 / 0 | 2.4 | Yes |
| 7345 |  CHEMBL179648 | C21H26N2O | 322.452 | 3 / 0 | 3.7 | Yes |
| 7450 |  CHEMBL377697 | C25H40N4O3S | 476.68 | 6 / 2 | 3.7 | Yes |
| 442020 |  CHEMBL3342852 | C19H28N2O3S | 364.504 | 6 / 0 | 2.5 | Yes |
| 547980 |  CHEMBL3983496 | C32H41N3O4 | 531.697 | 6 / 1 | 5.2 | No |
| 7856 |  CHEMBL63114 | C14H15N3S | 257.355 | 3 / 0 | 4.2 | Yes |
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