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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Homo sapiens (Human)
Gene	HTR1A
Synonym	5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Gpcr18 ADRB2RL1 ADRBRL1 G-21 [ Show all ]
Disease	Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder Major depressive disorder Major depressive disorder; Episode; Anxiety Migraine Mood disorder Pain Parkinson's disease Premature ejaculation Psychiatric disorder Psychotic disorders Schizoaffective disorder; Schizophrenia Severe mood disorders Unspecified Female sexual dysfunction Eating disorder Schizophrenia Alzheimer disease Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis Bulimia nervosa; Severe mood disorders Cervical dystonia; Spasm Cognitive disorders Anxiety disorder Depression Coronary artery disease [ Show all ]
Length	422
Amino acid sequence	MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
UniProt	P08908
Protein Data Bank	N/A
GPCR-HGmod model	P08908
3D structure model	This predicted structure model is from GPCR-EXP P08908.
BioLiP	N/A
Therapeutic Target Database	T78709
ChEMBL	CHEMBL214
IUPHAR	1
DrugBank	BE0000291

Ligand

Name	2-Phenylcyclopropanamine
Molecular formula	C9H11N
IUPAC name	2-phenylcyclopropan-1-amine
Molecular weight	133.194
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.5
Synonyms	(+/-)-trans-2-phenylcyclopropylamine Parnitene (1S)-2-phenylcyclopropan-1-amine SKF Trans-385 Tranilcipromina AELCINSCMGFISI-UHFFFAOYSA-N Transapin (TN) CCRIS 3344 Tranylcyprominum [INN-Latin] Cyclopropanamine, trans-(.+-.)- EN300-54719 Jatrosom l-Tranylcypromine NCGC00162316-01 (.+/-.)-trans-2-Phenylcyclopropamine SBB084038 Spectrum3_001068 54-97-7 trans-(-)-2-Phenylcyclopropanamine BDBM50113851 Tranylcypromine (INN) CHEMBL313833 US8609708, 6 Tranylcypromine Cyclopropylamine, trans-2-phenyl- GJZ KBio2_004646 LS-58824 NSC80664 Parnate (Salt/Mix) (1R,2S)-2-phenylcyclopropan-1-amine Sicoton (TN) 2-Phenyl-cyclopropylamine Spectrum_001598 AC1Q1HO9 Transamine C9H11N Tranylcypromine,(-) Cyclopropanamine, 2-phenyl-, (1R-trans)-(9CI) dl-Tranylcypromine GTPL5281 KBioGR_001658 NCGC00015848-03 (+)-trans-2-Phenylcyclopropylamine (+/-)-Tranylcypromine Parstelin (TN) (1S,2S)-2-phenylcyclopropan-1-amine SKF-trans-385 2-phenylcyclopropylamine Tranilcipromina [INN-Spanish] AKOS005217104 Tranylcypromin CHEBI:131512 Tylciprine (TN) Cyclopropylamine, 2-phenyl-, trans-(+-)- esparma Brand of Tranylcypromine Sulfate Jatrosom (TN) Link Brand of Tranylcypromine Sulfate NSC 80664 Parmodalin (TN) (.+/-.)-trans-2-Phenylcyclopropylamine SC-66350 2- Amino-cyclopropylbenzene Spectrum4_001219 AB01007711-01 trans-2-Phenylcyclopropylamine BRN 3195803 Tranylcypromine [INN:BAN] CTK1F7780 D0H0HJ GlaxoSmithKline Brand of Tranylcypromine Sulfate KBio2_007214 MCULE-7015811838 Parnate (TN) (1R,2R)-2-phenylcyclopropan-1-amine SKF 385 2-phenylcyclopropan-1-amine Sulfate, Tranylcypromine AC1Q53BI Transamine (TN) CCG-40399 Tranylcyprominum Cyclopropanamine, 2-phenyl-, trans-(+-)- EINECS 205-841-9 HSDB 3404 KBioSS_002078 NCGC00015848-04 (+)-Tranylcypromine (-)-Tranylcypromine Racemic Tranylcypromine (2S)-2-phenylcyclopropan-1-amine SmithKline Brand of Tranylcypromine Sulfate trans 2 Phenylcyclopropylamine Allphar Brand of Tranylcypromine Sulfate tranylcypromine US8609708, 6 Tranyl- cypromine Cyclopropylamine, trans-(.+-.)- F2173-0870 KBio2_002078 Lopac0_001013 NSC-80664 Parnate (.+/-.)-Tranylcypromine SCHEMBL40651 2-PCPA Spectrum5_001829 AC1L1KJT trans-DL-2-Phenylcyclopropylamine BS-13286 Tranylcypromine,(+) Cyclopropanamine, 2-phenyl- DB00752 Goldshield Brand of Tranylcypromine Sulfate KBio3_001876 NCGC00015848-02 [ Show all ]
Inchi Key	AELCINSCMGFISI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2
PubChem CID	5530
ChEMBL	CHEMBL313833
IUPHAR	N/A
BindingDB	50113851
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5963.0 nM	PMID9686407	PDSP,BindingDB

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