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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Homo sapiens (Human)
Gene	HTR1A
Synonym	5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Gpcr18 ADRB2RL1 ADRBRL1 G-21 [ Show all ]
Disease	Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder Major depressive disorder Major depressive disorder; Episode; Anxiety Migraine Mood disorder Pain Parkinson's disease Premature ejaculation Psychiatric disorder Psychotic disorders Schizoaffective disorder; Schizophrenia Severe mood disorders Unspecified Female sexual dysfunction Eating disorder Schizophrenia Alzheimer disease Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis Bulimia nervosa; Severe mood disorders Cervical dystonia; Spasm Cognitive disorders Anxiety disorder Depression Coronary artery disease [ Show all ]
Length	422
Amino acid sequence	MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
UniProt	P08908
Protein Data Bank	N/A
GPCR-HGmod model	P08908
3D structure model	This predicted structure model is from GPCR-EXP P08908.
BioLiP	N/A
Therapeutic Target Database	T78709
ChEMBL	CHEMBL214
IUPHAR	1
DrugBank	BE0000291

Ligand

Name	MLS000078794
Molecular formula	C11H13N5O
IUPAC name	4-(6-pyrazol-1-ylpyrimidin-4-yl)morpholine
Molecular weight	231.259
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	0.6
Synonyms	4-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]morpholine MCULE-7149871387 ZINC1243858 BDBM30751 regid860241 4-(6-pyrazol-1-ylpyrimidin-4-yl)morpholine cid_661544 SR-01000112168-1 AC1LD5HF 183552-72-9 SMR000035563 4-[6-(1-pyrazolyl)-4-pyrimidinyl]morpholine HMS2413B14 STK550979 AKOS005478457 MolPort-000-717-478 CHEMBL1583836 SR-01000112168 [ Show all ]
Inchi Key	AEVPAXFUKWMYSW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H13N5O/c1-2-14-16(3-1)11-8-10(12-9-13-11)15-4-6-17-7-5-15/h1-3,8-9H,4-7H2
PubChem CID	661544
ChEMBL	CHEMBL1583836
IUPHAR	N/A
BindingDB	30751
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	99000.0 nM	N/A	BindingDB

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