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Name | 5-hydroxytryptamine receptor 1A |
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Species | Homo sapiens (Human) |
Gene | HTR1A |
Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
Length | 422 |
Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
UniProt | P08908 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08908 |
3D structure model | This predicted structure model is from GPCR-EXP P08908. |
BioLiP | N/A |
Therapeutic Target Database | T78709 |
ChEMBL | CHEMBL214 |
IUPHAR | 1 |
DrugBank | BE0000291 |
Name | CHEMBL2159481 |
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Molecular formula | C24H24F2N2O3S |
IUPAC name | 3,4-difluoro-N-[1-[2-(2-phenylphenoxy)ethyl]pyrrolidin-3-yl]benzenesulfonamide |
Molecular weight | 458.524 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.6 |
Synonyms | BDBM50393387 |
Inchi Key | AJRQMVCEFKRUBB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H24F2N2O3S/c25-22-11-10-20(16-23(22)26)32(29,30)27-19-12-13-28(17-19)14-15-31-24-9-5-4-8-21(24)18-6-2-1-3-7-18/h1-11,16,19,27H,12-15,17H2 |
PubChem CID | 71449643 |
ChEMBL | CHEMBL2159481 |
IUPHAR | N/A |
BindingDB | 50393387 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Ki | 92.0 nM | PMID22926225 | BindingDB,ChEMBL |
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