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| Name | Kappa-type opioid receptor |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Oprk1 |
| Synonym | K-OR-1 kappa receptor KOP KOPr KOR-1 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 380 |
| Amino acid sequence | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV |
| UniProt | P34975 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL3614 |
| IUPHAR | 318 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 463062 |  CHEMBL3634916 | C68H105N23O13 | 1452.74 | 18 / 20 | -3.6 | No |
| 1603 |  N-Cyclopropylmethylnorazidomorphine | C20H24N4O2 | 352.438 | 5 / 1 | 4.1 | Yes |
| 2414 |  CHEMBL595015 | C22H28N4O | 364.493 | 4 / 0 | 4.8 | Yes |
| 4641 |  CHEMBL593613 | C21H26N4O | 350.466 | 4 / 1 | 4.5 | Yes |
| 553267 |  Dynorphin B | C74H115N21O17 | 1570.86 | 21 / 22 | -3.6 | No |
| 5384 |  CHEMBL353990 | C21H31N3O | 341.499 | 3 / 1 | 4.2 | Yes |
| 517366 |  CHEMBL159838 | C29H38FN5O3S | 555.713 | 7 / 0 | 5.8 | No |
| 9919 |  CHEMBL175116 | C39H56N8O10 | 796.923 | 11 / 10 | -1.0 | No |
| 11325 |  Norbinaltorphimine | C40H43N3O6 | 661.799 | 8 / 5 | 3.2 | No |
| 11348 |  CHEMBL93614 | C22H29NO2 | 339.479 | 3 / 2 | 4.5 | Yes |
| 12192 |  CHEMBL415795 | C64H106N22O12 | 1375.69 | 17 / 19 | -2.4 | No |
| 12196 |  CHEMBL262963 | C64H106N22O12 | 1375.69 | 17 / 19 | -2.4 | No |
| 13294 |  CHEMBL1082013 | C15H17NO2 | 243.306 | 3 / 1 | 2.6 | Yes |
| 15420 |  CHEMBL2310916 | C29H32N2O10 | 568.579 | 11 / 4 | N/A | No |
| 521938 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 16921 |  CHEMBL73349 | C18H25BrN2OS | 397.375 | 3 / 0 | 3.3 | Yes |
| 17357 |  CHEMBL2048967 | C19H23NO | 281.399 | 2 / 0 | 3.7 | Yes |
| 17975 |  CHEMBL405057 | C60H98N22O12 | 1319.59 | 17 / 19 | -4.1 | No |
| 17976 |  CHEMBL407084 | C60H98N22O12 | 1319.59 | 17 / 19 | -4.1 | No |
| 18025 |  CHEMBL1080674 | C17H21NO2 | 271.36 | 3 / 1 | 3.5 | Yes |
| 18219 |  CHEMBL139081 | C20H20BrNS | 386.351 | 2 / 0 | 5.8 | No |
| 19665 |  CHEMBL355202 | C25H25N3O | 383.495 | 3 / 1 | 4.5 | Yes |
| 19800 |  CHEMBL98626 | C22H28ClNO | 357.922 | 2 / 1 | 6.1 | No |
| 20863 |  CHEMBL170594 | C24H33N3O3 | 411.546 | 4 / 3 | 3.4 | Yes |
| 522118 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522208 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22367 |  CHEMBL346163 | C16H23NO | 245.366 | 2 / 1 | 3.4 | Yes |
| 23292 |  BDBM50066532 | C32H31ClN2O4 | 543.06 | 5 / 1 | 5.1 | No |
| 23293 |  CHEMBL610028 | C32H31ClN2O4 | 543.06 | 5 / 1 | 5.1 | No |
| 25231 |  CHEMBL97509 | C21H33NO | 315.501 | 2 / 1 | 6.2 | No |
| 28011 |  CHEMBL607066 | C25H35N3O2 | 409.574 | 4 / 0 | 4.8 | Yes |
| 28012 |  BDBM50098448 | C25H35N3O2 | 409.574 | 4 / 0 | 4.8 | Yes |
| 28017 |  CHEMBL607065 | C25H35N3O2 | 409.574 | 4 / 0 | 4.8 | Yes |
| 442769 |  CHEMBL3331510 | C50H62N10O10S2 | 1027.23 | 14 / 12 | 2.3 | No |
| 442771 |  CHEMBL3331511 | C50H62N10O10S2 | 1027.23 | 14 / 12 | 2.3 | No |
| 30353 |  morphine | C17H19NO3 | 285.343 | 4 / 2 | 0.8 | Yes |
| 30367 |  Morphinan-3,6.alpha.-diol, 7,8-didehydro-4,5.alpha.-epoxy-17-methyl- | C17H19NO3 | 285.343 | 4 / 2 | 0.8 | Yes |
| 31356 |  CHEMBL656 | C18H21NO4 | 315.369 | 5 / 1 | 1.2 | Yes |
| 31368 |  oxycodone | C18H21NO4 | 315.369 | 5 / 1 | 1.2 | Yes |
| 31400 |  Compound Venorphin | C77H117N25O13 | 1600.94 | 18 / 25 | -0.3 | No |
| 32921 |  CHEMBL79443 | C29H32N2O3 | 456.586 | 4 / 3 | 4.9 | Yes |
| 32986 |  CHEMBL2048965 | C21H33NO5 | 379.497 | 6 / 2 | N/A | N/A |
| 34418 |  CHEMBL76527 | C23H33N3O2 | 383.536 | 4 / 4 | 3.3 | Yes |
| 34421 |  CHEMBL76527 | C23H33N3O2 | 383.536 | 4 / 4 | 3.3 | Yes |
| 36450 |  CHEMBL364058 | C23H32O8 | 436.501 | 8 / 0 | 2.2 | Yes |
| 37164 |  Etorphine | C25H33NO4 | 411.542 | 5 / 2 | 3.1 | Yes |
| 37479 |  CID 44459074 | C73H105N23O14 | 1528.79 | 18 / 21 | -3.5 | No |
| 37720 |  Norbinaltorphimine (norBNI) | C40H43N3O6 | 661.799 | 8 / 5 | 3.2 | No |
| 39052 |  CHEMBL106872 | C30H42N6O6 | 582.702 | 7 / 6 | 1.5 | No |
| 467795 |  CHEMBL3634918 | C59H93N23O13 | 1332.54 | 18 / 20 | -6.6 | No |
| 40533 |  CHEMBL605307 | C22H28N4O | 364.493 | 4 / 0 | 4.8 | Yes |
| 41901 |  AM-1638 | C33H35FO4 | 514.637 | 5 / 1 | 7.8 | No |
| 468366 |  CHEMBL3634920 | C62H97N23O13 | 1372.61 | 18 / 20 | -5.9 | No |
| 468489 |  CHEMBL3634922 | C65H95N23O14 | 1422.62 | 18 / 20 | -5.2 | No |
| 48457 |  CHEMBL1210154 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 48475 |  SCHEMBL4318956 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 517558 |  CHEMBL72949 | C34H46FN7O4S | 667.845 | 7 / 0 | 3.8 | No |
| 48669 |  CHEMBL1254974 | C29H37N5O5 | 535.645 | 6 / 4 | 1.2 | No |
| 48671 |  CHEMBL1255058 | C29H37N5O5 | 535.645 | 6 / 4 | 1.2 | No |
| 443629 |  CHEMBL3397594 | C31H44FN3O3 | 525.709 | 6 / 3 | 5.8 | No |
| 553472 |  Cebranopadol | C24H27FN2O | 378.491 | 3 / 1 | 4.3 | Yes |
| 52280 |  CHEMBL2048971 | C23H29NO5 | 399.487 | 6 / 2 | N/A | N/A |
| 469556 |  CHEMBL3634917 | C69H107N23O13 | 1466.76 | 18 / 20 | -3.1 | No |
| 54570 |  CHEMBL75223 | C18H25N3O3 | 331.416 | 4 / 0 | 2.8 | Yes |
| 55236 |  CHEMBL81355 | C29H26N2O3 | 450.538 | 4 / 3 | 4.1 | Yes |
| 56255 |  CHEMBL269849 | C28H30O7 | 478.541 | 7 / 0 | 4.1 | Yes |
| 56437 |  CHEMBL106101 | C29H38N6O6 | 566.659 | 7 / 5 | 1.2 | No |
| 57242 |  CHEMBL370680 | C22H26O8 | 418.442 | 8 / 0 | 2.5 | Yes |
| 57841 |  CHEMBL543970 | C20H28BrN3OS | 438.428 | 4 / 1 | N/A | N/A |
| 57842 |  CHEMBL537701 | C20H28BrN3OS | 438.428 | 4 / 1 | N/A | N/A |
| 57928 |  BDBM86261 | C19H23NO4 | 329.396 | 5 / 1 | 1.5 | Yes |
| 443980 |  Biphalin | C46H56N10O10 | 909.014 | 12 / 12 | 1.4 | No |
| 59192 |  CHEMBL330138 | C19H25NOS | 315.475 | 3 / 1 | 4.8 | Yes |
| 59301 |  CHEMBL171763 | C23H31N3O3 | 397.519 | 4 / 4 | 3.1 | Yes |
| 59302 |  UNII-F156J3SXVX | C23H31N3O3 | 397.519 | 4 / 4 | 3.1 | Yes |
| 59510 |  CHEMBL608245 | C28H30N2O3 | 442.559 | 4 / 2 | 4.3 | Yes |
| 59514 |  BDBM50290388 | C28H30N2O3 | 442.559 | 4 / 2 | 4.3 | Yes |
| 60705 |  CHEMBL610286 | C32H33ClN2O6 | 577.074 | 7 / 1 | 4.9 | No |
| 60706 |  BDBM50066531 | C32H33ClN2O6 | 577.074 | 7 / 1 | 4.9 | No |
| 62562 |  CHEMBL415818 | C71H108N24O14 | 1521.8 | 20 / 22 | -6.0 | No |
| 62564 |  CHEMBL405721 | C71H108N24O14 | 1521.8 | 20 / 22 | -6.0 | No |
| 63232 |  CHEMBL76816 | C23H32N2O4 | 400.519 | 5 / 4 | 2.5 | Yes |
| 63234 |  CHEMBL76816 | C23H32N2O4 | 400.519 | 5 / 4 | 2.5 | Yes |
| 65212 |  CHEMBL2048970 | C20H27NO | 297.442 | 2 / 0 | 4.4 | Yes |
| 65542 |  CHEMBL149414 | C19H25NO2 | 299.414 | 3 / 1 | 3.8 | Yes |
| 66188 |  naltrexone | C20H23NO4 | 341.407 | 5 / 2 | 1.9 | Yes |
| 66996 |  CHEMBL431266 | C22H35NO | 329.528 | 2 / 1 | 6.6 | No |
| 68204 |  CHEMBL317097 | C20H27NOS | 329.502 | 3 / 1 | 5.1 | No |
| 69768 |  CHEMBL102040 | C30H36N2O2 | 456.63 | 3 / 0 | 4.3 | Yes |
| 69769 |  BDBM50088375 | C30H37N2O2+ | 457.638 | 2 / 1 | 4.3 | Yes |
| 70172 |  CHEMBL334511 | C31H35NO4 | 485.624 | 5 / 1 | 5.1 | No |
| 471590 |  CHEMBL3634925 | C62H90N20O13 | 1323.53 | 17 / 18 | -3.9 | No |
| 72705 |  CHEMBL178895 | C26H35N3O | 405.586 | 3 / 0 | 5.5 | No |
| 72712 |  CHEMBL22650 | C26H35N3O | 405.586 | 3 / 0 | 5.5 | No |
| 444578 |  Osanetant | C35H41Cl2N3O2 | 606.632 | 3 / 0 | 7.0 | No |
| 75102 |  CHEMBL2048970 | C22H29NO5 | 387.476 | 6 / 2 | N/A | N/A |
| 76374 |  ondansetron | C18H19N3O | 293.37 | 2 / 0 | 2.3 | Yes |
| 80863 |  CHEMBL2112374 | C28H31N5O3 | 485.588 | 5 / 5 | 1.7 | Yes |
| 82237 |  CHEMBL337272 | C30H39NO4 | 477.645 | 5 / 1 | 5.5 | No |
| 82553 |  CHEMBL17336 | C20H27N3OS | 357.516 | 4 / 0 | 4.8 | Yes |
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