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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL355202
Molecular formula	C25H25N3O
IUPAC name	8-[(1R)-1,2-dihydroacenaphthylen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight	383.495
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.5
Synonyms	(R)-Ro 65-6570 SCHEMBL6838730 (R)-Ro65-6570 8-(R)-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one BDBM50087698 1-Phenyl-8-[(1R)-acenaphthen-1-yl]-1,3,8-triazaspiro[4.5]decan-4-one GTPL8864 8-[(1R)-1,2-dihydroacenaphthylen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one [ Show all ]
Inchi Key	BBOAHBVXCYBKLC-JOCHJYFZSA-N
Inchi ID	InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)/t22-/m1/s1
PubChem CID	15512229
ChEMBL	CHEMBL355202
IUPHAR	8864
BindingDB	50087698
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
19668	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
19666	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
19656	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
19661	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
19660	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
19673	Corticotropin-releasing factor receptor 1	P35353	Crhr1	Rattus norvegicus (Rat)	415
19664	D(1A) dopamine receptor	Q61616	Drd1	Mus musculus (Mouse)	446
19667	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
19671	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
19670	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
19669	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
19672	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
19663	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
19665	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
19658	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
19662	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
19657	Nociceptin receptor	P35370	Oprl1	Rattus norvegicus (Rat)	367
19659	Nociceptin receptor	P41146	OPRL1	Homo sapiens (Human)	370

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