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| Name | Mu-type opioid receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | OPRM1 |
| Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
| Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
| Length | 400 |
| Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
| UniProt | P35372 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P35372 |
| 3D structure model | This predicted structure model is from GPCR-EXP P35372. |
| BioLiP | N/A |
| Therapeutic Target Database | T47768 |
| ChEMBL | CHEMBL233 |
| IUPHAR | 319 |
| DrugBank | BE0000770 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 135 |  CHEMBL1762411 | C35H45N5O2 | 567.778 | 6 / 4 | 6.2 | No |
| 167 |  CHEMBL2381177 | C30H37N3O4 | 503.643 | 6 / 3 | 5.8 | No |
| 441672 |  CHEMBL3409110 | C29H32FNO2 | 445.578 | 4 / 1 | 7.1 | No |
| 469 |  CHEMBL1642761 | C24H30N2 | 346.518 | 2 / 1 | 5.4 | No |
| 521451 |  CHEMBL3759541 | C35H36N4O4 | 576.697 | 5 / 3 | 4.7 | No |
| 566 |  CHEMBL438965 | C25H25ClN2 | 388.939 | 1 / 1 | 6.4 | No |
| 441698 |  CHEMBL3394753 | C35H51FN4O4 | 610.815 | 8 / 2 | 6.2 | No |
| 726 |  CHEMBL307327 | C27H34N2O2 | 418.581 | 3 / 0 | 5.2 | No |
| 860 |  CHEMBL125742 | C23H31N3O2 | 381.52 | 4 / 1 | 3.0 | Yes |
| 949 |  CHEMBL2397017 | C30H29N3O4 | 495.579 | 6 / 2 | 4.2 | Yes |
| 1029 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 557337 |  SCHEMBL16034373 | C29H39N3O6 | 525.646 | 7 / 4 | 1.7 | No |
| 547913 |  CHEMBL3899312 | C29H39N3O6 | 525.646 | 7 / 4 | 1.7 | No |
| 1342 |  SR-01000300690 | C22H22N4O3 | 390.443 | 4 / 2 | 2.5 | Yes |
| 1380 |  CHEMBL235154 | C22H21N3O2 | 359.429 | 4 / 1 | 3.0 | Yes |
| 1532 |  SB-0304 | C25H29N5O5 | 479.537 | 6 / 4 | -0.2 | Yes |
| 1536 |  CHEMBL1834250 | C25H29N5O5 | 479.537 | 6 / 4 | -0.2 | Yes |
| 521478 |  CHEMBL3814950 | C26H36N4O2 | 436.6 | 5 / 3 | 3.5 | Yes |
| 1565 |  CHEMBL199111 | C24H31N3O5S | 473.588 | 7 / 2 | 1.9 | Yes |
| 1568 |  CHEMBL2158955 | C47H61N9O8S | 912.12 | 10 / 9 | 3.2 | No |
| 1858 |  CHEMBL260169 | C31H39N3O3S | 533.731 | 5 / 0 | 6.5 | No |
| 2148 |  CHEMBL188841 | C14H21NO | 219.328 | 2 / 1 | 3.2 | Yes |
| 521509 |  CHEMBL3785839 | C24H29N3O | 375.516 | 2 / 1 | 3.6 | Yes |
| 521513 |  CHEMBL3759981 | C43H51N7O7 | 777.923 | 8 / 8 | 3.4 | No |
| 2290 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 547924 |  CHEMBL3977305 | C27H31NO4 | 433.548 | 5 / 2 | 3.8 | Yes |
| 557372 |  SCHEMBL878409 | C27H31NO4 | 433.548 | 5 / 2 | 3.8 | Yes |
| 547927 |  CHEMBL3945795 | C15H25NO | 235.371 | 2 / 0 | 2.6 | Yes |
| 2967 |  CHEMBL415223 | C37H44N2O2 | 548.771 | 3 / 2 | 8.1 | No |
| 3150 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 441839 |  CHEMBL3361419 | C24H34N6O3 | 454.575 | 6 / 4 | 1.7 | Yes |
| 3180 |  CHEMBL377340 | C18H19N3O | 293.37 | 3 / 1 | 4.1 | Yes |
| 535992 |  SCHEMBL1532866 | C18H23N3O2 | 313.401 | 4 / 2 | 2.6 | Yes |
| 3228 |  MLS000859925 | C34H41N5O8S | 679.789 | 9 / 4 | N/A | No |
| 3230 |  Dihydroergotamine mesylate | C34H41N5O8S | 679.789 | 9 / 4 | N/A | No |
| 3239 |  CHEMBL124642 | C23H31N3O | 365.521 | 3 / 0 | 3.5 | Yes |
| 3410 |  MLS001217465 | C23H24N2O7 | 440.452 | 8 / 2 | N/A | N/A |
| 3439 |  CHEMBL2113273 | C24H41N3O | 387.612 | 2 / 0 | 5.2 | No |
| 3487 |  CHEMBL66387 | C33H36N2O2 | 492.663 | 3 / 0 | 6.6 | No |
| 3522 |  CHEMBL38576 | C21H24Cl2N2O | 391.336 | 2 / 0 | 4.6 | Yes |
| 3535 |  CHEMBL320882 | C21H24Cl2N2O | 391.336 | 2 / 0 | 4.6 | Yes |
| 463320 |  MLS004801940 | C17H24BrN3O3 | 398.301 | 6 / 1 | 2.4 | Yes |
| 3559 |  MLS000735483 | C22H28ClNO | 357.922 | 2 / 1 | 5.1 | No |
| 3578 |  CHEMBL259263 | C30H38N4O3S | 534.719 | 6 / 0 | 5.8 | No |
| 3680 |  MLS001172392 | C16H17Cl2N3O | 338.232 | 3 / 1 | 3.3 | Yes |
| 3708 |  AC1NW0NQ | C14H13NO4S | 291.321 | 5 / 0 | 2.5 | Yes |
| 3867 |  CHEMBL228740 | C22H23NOS | 349.492 | 3 / 1 | 4.3 | Yes |
| 3938 |  CHEMBL364398 | C23H37N3O3S | 435.627 | 6 / 1 | 3.3 | Yes |
| 521558 |  CHEMBL3809808 | C26H29NO2 | 387.523 | 3 / 1 | 4.8 | Yes |
| 4090 |  CHEMBL362240 | C30H36ClN5O2 | 534.101 | 4 / 1 | 5.4 | No |
| 521562 |  CHEMBL3815013 | C25H34N4O2 | 422.573 | 5 / 3 | 3.0 | Yes |
| 4340 |  talipexole hydrochloride | C10H16ClN3S | 245.769 | 4 / 2 | N/A | N/A |
| 4659 |  120-78-5 | C14H8N2S4 | 332.472 | 6 / 0 | 5.6 | No |
| 4700 |  CHEMBL2334770 | C35H38N6O5 | 622.726 | 6 / 6 | 2.3 | No |
| 4703 |  CHEMBL2334768 | C35H38N6O5 | 622.726 | 6 / 6 | 2.3 | No |
| 4717 |  CHEMBL480619 | C21H31N3 | 325.5 | 2 / 0 | 5.0 | Yes |
| 521606 |  CHEMBL3747317 | C27H39Cl2N3O4 | 540.526 | 6 / 5 | N/A | No |
| 4920 |  CHEMBL332697 | C23H24N4O6 | 452.467 | 6 / 1 | 2.7 | Yes |
| 4939 |  CHEMBL319589 | C28H29NO4 | 443.543 | 5 / 1 | 5.1 | No |
| 4998 |  CHEMBL369786 | C25H33N3O2 | 407.558 | 3 / 1 | 5.8 | No |
| 5177 |  MLS000714572 | C22H30N2O6 | 418.49 | 6 / 2 | 2.5 | Yes |
| 5185 |  CHEMBL481707 | C29H35N3O | 441.619 | 3 / 0 | 7.1 | No |
| 553266 |  Dynorphin B | C74H115N21O17 | 1570.86 | 21 / 22 | -3.6 | No |
| 536067 |  CHEMBL3927136 | C30H42N2O5 | 510.675 | 7 / 2 | 4.4 | No |
| 463525 |  CHEMBL3597077 | C84H139N21O24 | 1827.16 | 28 / 25 | -4.1 | No |
| 5541 |  CHEMBL209380 | C27H33FN2O | 420.572 | 3 / 1 | 4.9 | Yes |
| 5582 |  CHEMBL365483 | C22H27NO | 321.464 | 2 / 1 | 5.3 | No |
| 5587 |  CID 44364817 | C42H46N6O8 | 762.864 | 9 / 7 | 0.6 | No |
| 5589 |  CHEMBL2370988 | C42H46N6O8 | 762.864 | 9 / 7 | 0.6 | No |
| 5590 |  CHEMBL2370989 | C42H46N6O8 | 762.864 | 9 / 7 | 0.6 | No |
| 5679 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 5823 |  H-Aba-Gly-Gly-Phe-Leu-OH | C29H37N7O6S | 611.718 | 10 / 7 | -0.2 | No |
| 533928 |  SCHEMBL3413519 | C32H38N6O2 | 538.696 | 8 / 1 | 6.5 | No |
| 557445 |  SCHEMBL14466685 | C27H30N4O4 | 474.561 | 6 / 4 | 2.3 | Yes |
| 441923 |  CHEMBL151416 | C29H36N2O | 428.62 | 3 / 1 | 6.5 | No |
| 6018 |  CHEMBL230253 | C23H31NO | 337.507 | 2 / 1 | 5.3 | No |
| 6056 |  CHEMBL195285 | C22H28N2O4 | 384.476 | 5 / 2 | 0.9 | Yes |
| 6064 |  CHEMBL273208 | C20H20N2O2 | 320.392 | 4 / 1 | 3.7 | Yes |
| 6173 |  CHEMBL3262366 | C34H43NO4 | 529.721 | 5 / 2 | 5.8 | No |
| 6180 |  CHEMBL61426 | C24H23F3N2O2 | 428.455 | 6 / 0 | 5.3 | No |
| 6347 |  CHEMBL2163917 | C33H36N6O6 | 612.687 | 7 / 6 | 1.5 | No |
| 6401 |  hesperetin | C16H14O6 | 302.282 | 6 / 3 | 2.4 | Yes |
| 441938 |  CHEMBL3394008 | C18H22N6O3S | 402.473 | 6 / 2 | 0.7 | Yes |
| 6489 |  3-(4-methylpiperazin-1-yl)phenol | C11H16N2O | 192.262 | 3 / 1 | 1.5 | Yes |
| 6620 |  MLS000401592 | C26H21FN4O5S2 | 552.595 | 9 / 3 | 5.1 | No |
| 6664 |  CHEMBL265195 | C28H29NO10 | 539.537 | 10 / 0 | 4.0 | No |
| 6784 |  spiropiperidine analogue, 11 | C28H31N3O | 425.576 | 3 / 0 | 5.4 | No |
| 463683 |  CHEMBL3597076 | C83H134N20O26 | 1828.1 | 29 / 25 | -6.6 | No |
| 6816 |  KUC104543N | C26H30N6O2 | 458.566 | 5 / 1 | 2.7 | Yes |
| 6922 |  CHEMBL382597 | C36H45N3O3 | 567.774 | 5 / 3 | 6.0 | No |
| 555508 |  MCL-145 | C46H58N2O4 | 702.98 | 6 / 0 | 10.6 | No |
| 6938 |  CHEMBL146756 | C46H58N2O4 | 702.98 | 6 / 0 | 10.6 | No |
| 463719 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 7007 |  CHEMBL3262546 | C25H30N2O | 374.528 | 2 / 0 | 4.8 | Yes |
| 7013 |  CHEMBL2322511 | C34H40N4O3 | 552.719 | 5 / 2 | 5.9 | No |
| 521654 |  CHEMBL3808879 | C27H31NO3 | 417.549 | 4 / 1 | 4.8 | Yes |
| 557488 |  SCHEMBL15486274 | C32H47NO7 | 557.728 | 8 / 0 | 3.4 | No |
| 547973 |  CHEMBL3959095 | C32H47NO7 | 557.728 | 8 / 0 | 3.4 | No |
| 7108 |  NSC612113 | C38H42N4O6 | 650.776 | 10 / 4 | 4.0 | No |
| 7113 |  Naloxonazine | C38H42N4O6 | 650.776 | 10 / 4 | 4.0 | No |
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