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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	CHEMBL362240
Molecular formula	C30H36ClN5O2
IUPAC name	3-[1-[2-[1-(2-chloro-5-methylphenoxy)cyclohexyl]-2-imidazol-1-ylethyl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular weight	534.101
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.4
Synonyms	1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-imidazol-1-yl-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one BDBM50159912
Inchi Key	AFEMFTNPESLYFE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H36ClN5O2/c1-22-9-10-24(31)27(19-22)38-30(13-5-2-6-14-30)28(35-18-15-32-21-35)20-34-16-11-23(12-17-34)36-26-8-4-3-7-25(26)33-29(36)37/h3-4,7-10,15,18-19,21,23,28H,2,5-6,11-14,16-17,20H2,1H3,(H,33,37)
PubChem CID	44391102
ChEMBL	CHEMBL362240
IUPHAR	N/A
BindingDB	50159912
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	477.0 nM	PMID15664818	BindingDB,ChEMBL

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