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Name | Mu-type opioid receptor |
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Species | Homo sapiens (Human) |
Gene | OPRM1 |
Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
Length | 400 |
Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P35372 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35372 |
3D structure model | This predicted structure model is from GPCR-EXP P35372. |
BioLiP | N/A |
Therapeutic Target Database | T47768 |
ChEMBL | CHEMBL233 |
IUPHAR | 319 |
DrugBank | BE0000770 |
Name | SCHEMBL1532866 |
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Molecular formula | C18H23N3O2 |
IUPAC name | 6-[4-[(3-methylbutylamino)methyl]phenoxy]pyridine-3-carboxamide |
Molecular weight | 313.401 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.6 |
Synonyms | CHEMBL3903895 |
Inchi Key | ADXBHKREPBWTDP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H23N3O2/c1-13(2)9-10-20-11-14-3-6-16(7-4-14)23-17-8-5-15(12-21-17)18(19)22/h3-8,12-13,20H,9-11H2,1-2H3,(H2,19,22) |
PubChem CID | 9904911 |
ChEMBL | CHEMBL3903895 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kb | 0.2 nM | None | ChEMBL |
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