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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	SCHEMBL3413519
Molecular formula	C32H38N6O2
IUPAC name	2-N-[4-(dimethylamino)-1,4-diphenylcyclohexyl]-6-(4-methoxyphenoxy)-2-N,4-N-dimethyl-1,3,5-triazine-2,4-diamine
Molecular weight	538.696
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	6.5
Synonyms	US9403767, 91 CHEMBL3896402 BDBM239917
Inchi Key	AHTGEUVXEZBNCV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H38N6O2/c1-33-28-34-29(36-30(35-28)40-27-18-16-26(39-5)17-19-27)38(4)32(25-14-10-7-11-15-25)22-20-31(21-23-32,37(2)3)24-12-8-6-9-13-24/h6-19H,20-23H2,1-5H3,(H,33,34,35,36)
PubChem CID	44253138
ChEMBL	CHEMBL3896402
IUPHAR	N/A
BindingDB	239917
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	740.0 nM	, None	BindingDB,ChEMBL

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