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Name | Mu-type opioid receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprm1 |
Synonym | Opioid receptor B opioid receptor OP3 mu receptor MOR-1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 398 |
Amino acid sequence | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P33535 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL270 |
IUPHAR | 319 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
270 | CHEMBL132776 | C31H43N7O8 | 641.726 | 9 / 9 | -0.4 | No |
574 | CHEMBL44172 | C25H31N5O7 | 513.551 | 8 / 7 | -3.4 | No |
589 | CHEMBL213366 | C47H69N7O3 | 780.115 | 10 / 9 | 5.3 | No |
593 | Tyr-Pro-Emp-Phe-NH2 | C35H43N5O5 | 613.759 | 6 / 5 | 3.8 | No |
627 | CHEMBL134023 | C32H44N8O8 | 668.752 | 9 / 9 | -0.8 | No |
694 | CHEMBL76086 | C31H41N5O7S2 | 659.817 | 10 / 7 | -0.3 | No |
697 | CHEMBL310681 | C31H41N5O7S2 | 659.817 | 10 / 7 | -0.3 | No |
701 | CHEMBL80626 | C31H41N5O7S2 | 659.817 | 10 / 7 | -0.3 | No |
706 | CHEMBL307614 | C31H41N5O7S2 | 659.817 | 10 / 7 | -0.3 | No |
463063 | CHEMBL3634916 | C68H105N23O13 | 1452.74 | 18 / 20 | -3.6 | No |
1229 | CHEMBL143800 | C23H25NO3 | 363.457 | 4 / 1 | 3.6 | Yes |
1438 | CHEMBL1929362 | C27H30N2O | 398.55 | 3 / 1 | 5.8 | No |
1511 | CHEMBL556537 | C70H89F6N11O15 | 1438.53 | 22 / 14 | 5.8 | No |
1530 | SB-0304 | C25H29N5O5 | 479.537 | 6 / 4 | -0.2 | Yes |
1767 | CHEMBL1186493 | C23H27ClN4 | 394.947 | 4 / 2 | 5.6 | No |
1842 | CHEMBL2310837 | C20H25ClN2O | 344.883 | 2 / 0 | 4.0 | Yes |
2053 | BDBM50027090 | C22H25BrN2O4 | 461.356 | 5 / 2 | 2.2 | Yes |
2055 | CHEMBL608248 | C22H25BrN2O4 | 461.356 | 5 / 2 | 2.2 | Yes |
441748 | CHEMBL3326662 | C33H50N6OS2 | 610.924 | 5 / 2 | 5.3 | No |
521514 | CHEMBL3759981 | C43H51N7O7 | 777.923 | 8 / 8 | 3.4 | No |
463227 | CHEMBL3609619 | C32H30F6N4O5 | 664.605 | 12 / 5 | 4.5 | No |
3169 | CHEMBL557188 | C60H72F6N10O9 | 1191.29 | 16 / 10 | 7.4 | No |
3241 | CHEMBL124642 | C23H31N3O | 365.521 | 3 / 0 | 3.5 | Yes |
547942 | CHEMBL95302 | C19H23N5O4 | 385.424 | 8 / 4 | 2.3 | Yes |
3553 | CHEMBL405672 | C53H71N11O10S2 | 1086.34 | 14 / 13 | 2.5 | No |
3569 | CHEMBL231049 | C24H31N3O2 | 393.531 | 3 / 1 | 2.7 | Yes |
3719 | CHEMBL451962 | C34H39N5O4 | 581.717 | 5 / 4 | 4.1 | No |
3901 | CHEMBL2371018 | C38H40N4O6 | 648.76 | 7 / 5 | 2.3 | No |
3904 | CHEMBL2371027 | C38H40N4O6 | 648.76 | 7 / 5 | 2.3 | No |
3946 | CHEMBL298893 | C16H24N2O2 | 276.38 | 3 / 1 | 2.4 | Yes |
3947 | CHEMBL609676 | C16H24N2O2 | 276.38 | 3 / 1 | 2.4 | Yes |
4453 | CHEMBL230943 | C27H31N3O2 | 429.564 | 3 / 1 | 4.1 | Yes |
4479 | H-Tyr-Tic-Cha-Phe-OH | C37H44N4O6 | 640.781 | 7 / 5 | 3.1 | No |
4482 | CHEMBL2371935 | C37H44N4O6 | 640.781 | 7 / 5 | 3.1 | No |
4825 | CHEMBL2338752 | C32H39NO4 | 501.667 | 5 / 2 | 5.2 | No |
5321 | CHEMBL161147 | C23H24ClN3O2 | 409.914 | 4 / 0 | 4.4 | Yes |
5387 | CHEMBL353990 | C21H31N3O | 341.499 | 3 / 1 | 4.2 | Yes |
463567 | CHEMBL3613884 | C27H34F3N3O3 | 505.582 | 8 / 2 | N/A | No |
5837 | BDBM50321606 | C80H98N18O14 | 1535.78 | 17 / 18 | 2.2 | No |
5871 | CHEMBL347750 | C21H28N2O2 | 340.467 | 3 / 3 | 3.5 | Yes |
5959 | CHEMBL151416 | C29H36N2O | 428.62 | 3 / 1 | 6.5 | No |
6029 | CHEMBL101072 | C37H54N4O3 | 602.864 | 5 / 4 | 5.9 | No |
6397 | CHEMBL385779 | C34H48N6O5 | 620.795 | 8 / 7 | 2.5 | No |
6492 | CHEMBL155797 | C30H34ClN3O2 | 504.071 | 4 / 1 | 6.1 | No |
521644 | CHEMBL3770677 | C27H31N3O2 | 429.564 | 4 / 4 | 4.6 | Yes |
6950 | CHEMBL102013 | C42H63N5O3 | 685.998 | 5 / 4 | 7.3 | No |
6966 | CID 69083551 | C24H29ClN6 | 436.988 | 4 / 3 | 5.0 | Yes |
7461 | CHEMBL1076738 | C52H60N10O8 | 953.114 | 10 / 10 | 3.0 | No |
7665 | CHEMBL278889 | C33H38N6O6 | 614.703 | 7 / 6 | 1.8 | No |
7948 | CHEMBL2048983 | C19H29NO5 | 351.443 | 6 / 2 | N/A | N/A |
8144 | CHEMBL557243 | C32H35N5O5 | 569.662 | 6 / 5 | 2.5 | No |
8361 | CHEMBL315603 | C32H50N8O10 | 706.798 | 11 / 10 | -3.1 | No |
8565 | CHEMBL3216028 | C23H30Cl4N4 | 504.321 | 4 / 5 | N/A | No |
8751 | CHEMBL3217121 | C24H30Cl4N6 | 544.346 | 4 / 6 | N/A | No |
8889 | CHEMBL409907 | C30H35N5O4 | 529.641 | 6 / 4 | 2.9 | No |
9156 | CHEMBL188565 | C18H24N4O | 312.417 | 3 / 2 | 2.2 | Yes |
9525 | CHEMBL121946 | C38H54N8O10 | 782.896 | 11 / 10 | -1.5 | No |
9639 | CHEMBL161512 | C18H22N2O2 | 298.386 | 3 / 1 | 3.1 | Yes |
9662 | CHEMBL149795 | C29H36N2O2 | 444.619 | 4 / 2 | 5.5 | No |
9918 | CHEMBL175116 | C39H56N8O10 | 796.923 | 11 / 10 | -1.0 | No |
9957 | CHEMBL387670 | C61H73F6N9O10 | 1206.3 | 17 / 8 | 8.1 | No |
10055 | H-Tyr-D-Ala-Gly-Phe-Met-NH2 | C28H38N6O6S | 586.708 | 8 / 7 | -0.1 | No |
11252 | CHEMBL159793 | C32H43N5O7S2 | 673.844 | 10 / 7 | 0.1 | No |
11261 | SCHEMBL9880436 | C25H28N2O7 | 468.506 | 8 / 4 | 1.3 | Yes |
11303 | CHEMBL422877 | C31H37N3O2 | 483.656 | 4 / 1 | 5.4 | No |
11330 | Norbinaltorphimine | C40H43N3O6 | 661.799 | 8 / 5 | 3.2 | No |
11349 | CHEMBL93614 | C22H29NO2 | 339.479 | 3 / 2 | 4.5 | Yes |
11612 | BDBM50098673 | C25H24N2O3 | 400.478 | 4 / 3 | 3.7 | Yes |
11615 | CHEMBL611697 | C25H24N2O3 | 400.478 | 4 / 3 | 3.7 | Yes |
11983 | CHEMBL346165 | C27H27N3O3 | 441.531 | 5 / 2 | 2.9 | Yes |
12085 | CHEMBL1089542 | C25H35N5O | 421.589 | 3 / 2 | 2.7 | Yes |
12155 | CHEMBL381793 | C28H27FN4O | 454.549 | 4 / 2 | 4.2 | Yes |
12189 | CHEMBL415795 | C64H106N22O12 | 1375.69 | 17 / 19 | -2.4 | No |
12194 | CHEMBL262963 | C64H106N22O12 | 1375.69 | 17 / 19 | -2.4 | No |
464402 | CHEMBL3580743 | C37H43F2N7O7 | 735.79 | 10 / 8 | 1.6 | No |
12984 | CHEMBL323024 | C29H38N6O6 | 566.659 | 7 / 7 | 0.4 | No |
13229 | CHEMBL146108 | C25H33N3O3 | 423.557 | 4 / 3 | 3.1 | Yes |
13378 | CHEMBL606959 | C34H35N3O6 | 581.669 | 8 / 5 | 1.7 | No |
13435 | CHEMBL2370599 | C20H32N4O5 | 408.499 | 6 / 6 | 0.4 | No |
536348 | CHEMBL91760 | C23H30N6O5 | 470.53 | 7 / 7 | -0.8 | No |
13720 | CHEMBL132775 | C33H46N8O8 | 682.779 | 9 / 9 | -0.9 | No |
521855 | CHEMBL3823054 | C33H51N9O5 | 653.829 | 8 / 9 | 0.4 | No |
14025 | CHEMBL1766208 | C61H74F6N10O9S | 1237.37 | 17 / 10 | 7.3 | No |
14085 | CHEMBL611925 | C57H64F6N10O9S2 | 1211.31 | 18 / 10 | 6.0 | No |
14090 | CHEMBL611924 | C57H64F6N10O9S2 | 1211.31 | 18 / 10 | 6.0 | No |
14189 | CHEMBL132164 | C41H59N9O9 | 821.977 | 10 / 10 | 1.2 | No |
464635 | CHEMBL3582484 | C37H44FN7O7 | 717.799 | 9 / 8 | 1.5 | No |
14428 | CHEMBL2369473 | C53H70N12O12S2 | 1131.33 | 16 / 14 | -0.4 | No |
14589 | CHEMBL2402930 | C32H43N9O6 | 649.753 | 8 / 8 | -0.8 | No |
14596 | CHEMBL327270 | C25H27ClN2O2 | 422.953 | 3 / 0 | 6.0 | No |
15134 | CHEMBL99496 | C18H27NOS | 305.48 | 3 / 1 | 2.9 | Yes |
15135 | CHEMBL97918 | C18H27NOS | 305.48 | 3 / 1 | 2.9 | Yes |
15136 | CHEMBL98817 | C18H27NOS | 305.48 | 3 / 1 | 2.9 | Yes |
15137 | CHEMBL98650 | C18H27NOS | 305.48 | 3 / 1 | 2.9 | Yes |
15523 | CHEMBL2371213 | C51H70N12O10S2 | 1075.31 | 15 / 14 | 0.5 | No |
15567 | CHEMBL572875 | C26H45N3 | 399.667 | 3 / 1 | 6.5 | No |
15716 | CHEMBL179350 | C27H32N2O5 | 464.562 | 7 / 0 | 3.2 | Yes |
15747 | BDBM50085059 | C47H63N13O11S3 | 1082.28 | 16 / 14 | -1.0 | No |
15852 | CHEMBL2338749 | C31H43NO4 | 493.688 | 5 / 2 | 5.6 | No |
16132 | H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl | C52H62N8O9 | 943.115 | 10 / 8 | 5.0 | No |
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