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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL323024
Molecular formula	C29H38N6O6
IUPAC name	(2S,5S,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2-methylphenyl)methyl]-3,8,14-trioxo-1,4,9-triazacyclotetradecane-5-carboxamide
Molecular weight	566.659
Hydrogen bond acceptor	7
Hydrogen bond donor	7
XlogP	0.4
Synonyms	BDBM50007330 13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2-(2-methyl-benzyl)-3,8,14-trioxo-1,4,9triaza-cyclotetradecane-5-carboxylic acid amide
Inchi Key	ASBSMCWBIMOGPZ-XQUALCHDSA-N
Inchi ID	InChI=1S/C29H38N6O6/c1-17-5-2-3-6-19(17)16-24-29(41)33-22(26(31)38)12-13-25(37)32-14-4-7-23(28(40)35-24)34-27(39)21(30)15-18-8-10-20(36)11-9-18/h2-3,5-6,8-11,21-24,36H,4,7,12-16,30H2,1H3,(H2,31,38)(H,32,37)(H,33,41)(H,34,39)(H,35,40)/t21-,22-,23+,24-/m0/s1
PubChem CID	15088044
ChEMBL	CHEMBL323024
IUPHAR	N/A
BindingDB	50007330
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.92 nM	PMID1656045	BindingDB,ChEMBL
Relative potency	4.91 -	PMID1656045	ChEMBL

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