Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL2402930
Molecular formula	C32H43N9O6
IUPAC name	(5S,8S,14R)-14-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-8-benzyl-7,10,13-trioxo-2-piperidin-1-yl-1,3,6,9,12-pentazacyclopentadec-2-ene-5-carboxamide
Molecular weight	649.753
Hydrogen bond acceptor	8
Hydrogen bond donor	8
XlogP	-0.8
Synonyms	N/A
Inchi Key	AUFPKYMBJJTQQY-ASDGIDEWSA-N
Inchi ID	InChI=1S/C32H43N9O6/c33-23(15-21-9-11-22(42)12-10-21)29(45)40-26-18-37-32(41-13-5-2-6-14-41)36-17-25(28(34)44)39-31(47)24(16-20-7-3-1-4-8-20)38-27(43)19-35-30(26)46/h1,3-4,7-12,23-26,42H,2,5-6,13-19,33H2,(H2,34,44)(H,35,46)(H,36,37)(H,38,43)(H,39,47)(H,40,45)/t23-,24-,25-,26+/m0/s1
PubChem CID	71761638
ChEMBL	CHEMBL2402930
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1445.44 nM	PMID23822516	ChEMBL
EC50	1945.0 nM	PMID23822516	ChEMBL
EC50	2071.0 nM	PMID23822516	ChEMBL
EC50	2692.0 nM	PMID23822516	ChEMBL
EC50	4168.69 nM	PMID23822516	ChEMBL
EC50	7585.78 nM	PMID23822516	ChEMBL
Emax	110.8 %	PMID23822516	ChEMBL
Emax	120.0 %	PMID23822516	ChEMBL
Emax	151.7 %	PMID23822516	ChEMBL
IC50	131.83 nM	PMID23822516	ChEMBL
IC50	416.87 nM	PMID23822516	ChEMBL
IC50	776.25 nM	PMID23822516	ChEMBL
Ki	107.0 nM	PMID23822516	ChEMBL
Ki	341.0 nM	PMID23822516	ChEMBL
Ki	637.0 nM	PMID23822516	ChEMBL

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417