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| Name | Nociceptin receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | OPRL1 |
| Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
| Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
| Length | 370 |
| Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
| UniProt | P41146 |
| Protein Data Bank | 5dhh, 5dhg, 4ea3 |
| GPCR-HGmod model | P41146 |
| 3D structure model | This structure is from PDB ID 5dhh. |
| BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
| Therapeutic Target Database | T52921 |
| ChEMBL | CHEMBL2014 |
| IUPHAR | 320 |
| DrugBank | BE0002378 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 134 |  CHEMBL1762411 | C35H45N5O2 | 567.778 | 6 / 4 | 6.2 | No |
| 565 |  CHEMBL438965 | C25H25ClN2 | 388.939 | 1 / 1 | 6.4 | No |
| 441697 |  CHEMBL3394753 | C35H51FN4O4 | 610.815 | 8 / 2 | 6.2 | No |
| 1101 |  CHEMBL541511 | C19H26F2N4 | 348.442 | 5 / 1 | 3.1 | Yes |
| 1768 |  CHEMBL1186493 | C23H27ClN4 | 394.947 | 4 / 2 | 5.6 | No |
| 1859 |  CHEMBL260169 | C31H39N3O3S | 533.731 | 5 / 0 | 6.5 | No |
| 521510 |  CHEMBL3785839 | C24H29N3O | 375.516 | 2 / 1 | 3.6 | Yes |
| 2424 |  CHEMBL513423 | C22H26ClFN2O2 | 404.91 | 5 / 2 | 3.1 | Yes |
| 3438 |  CHEMBL2113273 | C24H41N3O | 387.612 | 2 / 0 | 5.2 | No |
| 3463 |  CHEMBL506803 | C27H26Cl2FN | 454.41 | 2 / 0 | 7.9 | No |
| 547940 |  CHEMBL95302 | C19H23N5O4 | 385.424 | 8 / 4 | 2.3 | Yes |
| 3577 |  CHEMBL259263 | C30H38N4O3S | 534.719 | 6 / 0 | 5.8 | No |
| 3864 |  CHEMBL228740 | C22H23NOS | 349.492 | 3 / 1 | 4.3 | Yes |
| 3939 |  CHEMBL364398 | C23H37N3O3S | 435.627 | 6 / 1 | 3.3 | Yes |
| 4089 |  CHEMBL362240 | C30H36ClN5O2 | 534.101 | 4 / 1 | 5.4 | No |
| 4574 |  CHEMBL454919 | C32H36Cl2N2 | 519.554 | 2 / 0 | 8.4 | No |
| 4649 |  arylpyrazole, 13 | C22H22Cl3N3 | 434.789 | 2 / 1 | 6.5 | No |
| 4716 |  CHEMBL480619 | C21H31N3 | 325.5 | 2 / 0 | 5.0 | Yes |
| 4999 |  CHEMBL369786 | C25H33N3O2 | 407.558 | 3 / 1 | 5.8 | No |
| 5184 |  CHEMBL481707 | C29H35N3O | 441.619 | 3 / 0 | 7.1 | No |
| 5540 |  CHEMBL209380 | C27H33FN2O | 420.572 | 3 / 1 | 4.9 | Yes |
| 533929 |  SCHEMBL3413519 | C32H38N6O2 | 538.696 | 8 / 1 | 6.5 | No |
| 6021 |  CHEMBL230253 | C23H31NO | 337.507 | 2 / 1 | 5.3 | No |
| 6172 |  CHEMBL3262366 | C34H43NO4 | 529.721 | 5 / 2 | 5.8 | No |
| 557455 |  CHEMBL210140 | C22H23FN4O | 378.451 | 5 / 1 | 4.6 | Yes |
| 6785 |  spiropiperidine analogue, 11 | C28H31N3O | 425.576 | 3 / 0 | 5.4 | No |
| 6967 |  CID 69083551 | C24H29ClN6 | 436.988 | 4 / 3 | 5.0 | Yes |
| 7006 |  CHEMBL3262546 | C25H30N2O | 374.528 | 2 / 0 | 4.8 | Yes |
| 7172 |  CHEMBL513303 | C32H36Cl2N2O | 535.553 | 3 / 1 | 7.5 | No |
| 7649 |  CHEMBL535844 | C25H28ClNO | 393.955 | 2 / 2 | N/A | N/A |
| 8417 |  arylpyrazole, 26 | C21H23Cl2N5 | 416.35 | 4 / 1 | 4.4 | Yes |
| 8754 |  CHEMBL320991 | C20H30ClNO | 335.916 | 2 / 1 | 5.5 | No |
| 9191 |  CHEMBL1079942 | C26H36N4O2 | 436.6 | 4 / 1 | 4.5 | Yes |
| 557552 |  CHEMBL208726 | C24H29N5O | 403.53 | 5 / 1 | 4.6 | Yes |
| 9658 |  CHEMBL468952 | C27H27Cl2NO | 452.419 | 2 / 1 | 6.9 | No |
| 10305 |  CHEMBL2204353 | C21H24ClFN2O2S | 422.943 | 5 / 1 | 3.6 | Yes |
| 10306 |  CHEMBL2204354 | C21H24ClFN2O2S | 422.943 | 5 / 1 | 3.6 | Yes |
| 10675 |  CHEMBL516801 | C29H31Cl2N3O2 | 524.486 | 4 / 1 | 6.2 | No |
| 11116 |  CHEMBL202604 | C26H29N3O2 | 415.537 | 3 / 2 | 4.4 | Yes |
| 11464 |  FGGFTCARKCARK | C62H102N22O14S2 | 1443.76 | 21 / 23 | -5.7 | No |
| 11684 |  spiropiperidine analogue, 36 | C35H42Cl2N4O | 605.648 | 4 / 1 | 8.2 | No |
| 11911 |  8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid Methyl Ester | C27H29N3O3 | 443.547 | 5 / 0 | 4.5 | Yes |
| 12593 |  CHEMBL1834415 | C29H40ClNO4 | 502.092 | 5 / 2 | 5.6 | No |
| 12729 |  CHEMBL181545 | C27H43N3O4S | 505.718 | 7 / 0 | 4.9 | No |
| 13084 |  CHEMBL233749 | C25H26Cl2N2O | 441.396 | 3 / 2 | 4.7 | Yes |
| 13936 |  CHEMBL3262553 | C31H36N2O | 452.642 | 2 / 0 | 6.8 | No |
| 14143 |  arylpyrazole, 22 | C21H24ClN5 | 381.908 | 4 / 1 | 3.8 | Yes |
| 15188 |  CHEMBL382257 | C29H40N2O | 432.652 | 2 / 1 | 6.4 | No |
| 15595 |  CHEMBL419272 | C25H24BrN3O | 462.391 | 3 / 1 | 5.1 | No |
| 15886 |  spiropiperidine analogue, 39 | C33H38Cl2N4O | 577.594 | 4 / 0 | 7.2 | No |
| 16126 |  CHEMBL379297 | C24H23N3 | 353.469 | 2 / 1 | 4.7 | Yes |
| 16541 |  CHEMBL395838 | C24H24FNO | 361.46 | 3 / 1 | 4.7 | Yes |
| 16549 |  CHEMBL513667 | C29H30Cl2N2O | 493.472 | 2 / 1 | 7.0 | No |
| 16720 |  CHEMBL2088049 | C21H23ClN2OS | 386.938 | 4 / 0 | 4.0 | Yes |
| 16731 |  CHEMBL550117 | C22H22Cl3N3 | 434.789 | 2 / 1 | 5.9 | No |
| 521970 |  CHEMBL3808523 | C77H106N24O13 | 1575.85 | 18 / 26 | 0.1 | No |
| 17016 |  CHEMBL512612 | C28H28Cl2N2O2 | 495.444 | 3 / 1 | 6.2 | No |
| 17324 |  CHEMBL198604 | C34H49N3O2 | 531.785 | 4 / 1 | 6.4 | No |
| 17453 |  CHEMBL228849 | C24H24ClNO | 377.912 | 2 / 1 | 5.2 | No |
| 17904 |  CHEMBL409351 | C32H40N4O3 | 528.697 | 5 / 0 | 5.7 | No |
| 18048 |  D0C9QV | C80H131N27O22 | 1823.09 | 27 / 27 | -10.8 | No |
| 18382 |  CHEMBL1079561 | C26H28N4O2 | 428.536 | 3 / 1 | 3.6 | Yes |
| 18389 |  CHEMBL182410 | C25H32ClN3O3 | 457.999 | 4 / 2 | 4.7 | Yes |
| 19367 |  CHEMBL211846 | C22H31FN2 | 342.502 | 2 / 1 | 6.2 | No |
| 19659 |  CHEMBL355202 | C25H25N3O | 383.495 | 3 / 1 | 4.5 | Yes |
| 19677 |  SCHEMBL8092935 | C25H25N3O | 383.495 | 3 / 1 | 4.5 | Yes |
| 19678 |  CHEMBL281274 | C25H25N3O | 383.495 | 3 / 1 | 4.5 | Yes |
| 19958 |  CHEMBL2088048 | C22H28ClNO2S | 405.981 | 4 / 0 | 4.4 | Yes |
| 20139 |  spiropiperidine analogue, 18 | C29H29N3O | 435.571 | 3 / 0 | 5.1 | No |
| 465418 |  CHEMBL3585387 | C24H27N3O7 | 469.494 | 9 / 3 | N/A | N/A |
| 20780 |  CHEMBL517733 | C27H29Cl2N3 | 466.45 | 3 / 1 | 6.0 | No |
| 20817 |  CHEMBL337128 | C24H20N4O4 | 428.448 | 6 / 2 | 4.0 | Yes |
| 21420 |  spiropiperidine analogue, 70 | C29H39ClN4O | 495.108 | 4 / 1 | 5.6 | No |
| 21980 |  CHEMBL2387198 | C23H34N2O | 354.538 | 2 / 0 | 4.7 | Yes |
| 522139 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522211 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22724 |  CHEMBL2204347 | C22H26ClFN2O2S | 436.97 | 5 / 1 | 4.0 | Yes |
| 22725 |  CHEMBL2204348 | C22H26ClFN2O2S | 436.97 | 5 / 1 | 4.0 | Yes |
| 22726 |  CHEMBL2088058 | C22H26ClFN2O2S | 436.97 | 5 / 1 | 4.0 | Yes |
| 548157 |  CHEMBL3955335 | C27H33FN2O2 | 436.571 | 4 / 1 | 5.5 | No |
| 24180 |  CHEMBL240941 | C31H44N4O4 | 536.717 | 5 / 1 | 5.4 | No |
| 24383 |  CHEMBL231866 | C27H29Cl2N3O2 | 498.448 | 3 / 3 | 4.8 | Yes |
| 24652 |  CHEMBL512896 | C23H30N2O2 | 366.505 | 4 / 2 | 2.7 | Yes |
| 25455 |  CHEMBL460093 | C28H29Cl2FN2 | 483.452 | 3 / 1 | 7.0 | No |
| 558062 |  CHEMBL211310 | C23H26N4O | 374.488 | 4 / 1 | 4.9 | Yes |
| 26320 |  CHEMBL315551 | C27H43N3 | 409.662 | 3 / 0 | 6.5 | No |
| 26876 |  CHEMBL467314 | C28H29Cl2N3O | 494.46 | 2 / 2 | 6.3 | No |
| 27024 |  BDBM50259285 | C27H26Cl2N2O | 465.418 | 3 / 0 | 6.9 | No |
| 27214 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 558090 |  CHEMBL211222 | C19H26N4O | 326.444 | 4 / 1 | 4.2 | Yes |
| 27297 |  CHEMBL392798 | C23H26FN3O | 379.479 | 4 / 1 | 4.0 | Yes |
| 27718 |  CHEMBL1762405 | C28H31N5O2 | 469.589 | 6 / 4 | 3.0 | Yes |
| 27848 |  BDBM50121253 | C80H132N28O21 | 1822.11 | 26 / 30 | -8.1 | No |
| 459458 |  [8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid | C30H33N3O3 | 483.612 | 5 / 1 | 2.9 | Yes |
| 28829 |  CHEMBL233721 | C21H27NO | 309.453 | 2 / 1 | 4.5 | Yes |
| 28947 |  CHEMBL200204 | C25H31N3O2 | 405.542 | 4 / 2 | 3.6 | Yes |
| 28949 |  CHEMBL211373 | C25H31N3O2 | 405.542 | 4 / 2 | 3.6 | Yes |
| 28952 |  CHEMBL200371 | C25H31N3O2 | 405.542 | 4 / 2 | 3.6 | Yes |
| 28985 |  CHEMBL378394 | C23H24ClN3O | 393.915 | 3 / 1 | 5.3 | No |
| 28999 |  CHEMBL424934 | C64H103N23O16S2 | 1514.79 | 23 / 23 | -6.9 | No |
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