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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL512612 |
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Molecular formula | C28H28Cl2N2O2 |
IUPAC name | 8-[bis(2-chlorophenyl)methyl]-3-(4-methoxyphenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide |
Molecular weight | 495.444 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 6.2 |
Synonyms | 8-(bis(2-chlorophenyl)methyl)-3-(4-methoxyphenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide BDBM50259351 |
Inchi Key | AXRTXOCKWKDAKF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H28Cl2N2O2/c1-34-21-14-10-18(11-15-21)28(27(31)33)16-19-12-13-20(17-28)32(19)26(22-6-2-4-8-24(22)29)23-7-3-5-9-25(23)30/h2-11,14-15,19-20,26H,12-13,16-17H2,1H3,(H2,31,33) |
PubChem CID | 44574850 |
ChEMBL | CHEMBL512612 |
IUPHAR | N/A |
BindingDB | 50259351 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 22.0 nM | PMID19339177 | BindingDB,ChEMBL |
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