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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL281274 |
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Molecular formula | C25H25N3O |
IUPAC name | 8-(1,2-dihydroacenaphthylen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 383.495 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | SCHEMBL2248376 1-Phenyl-8-(acenaphthen-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one 8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one BDBM50087016 Ro65-6570 [ Show all ] |
Inchi Key | BBOAHBVXCYBKLC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29) |
PubChem CID | 10022859 |
ChEMBL | CHEMBL281274 |
IUPHAR | N/A |
BindingDB | 50087016 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 40.0 nM | PMID10753470 | BindingDB,ChEMBL |
Ki | 0.52 nM | PMID10753470 | ChEMBL |
Ki | 0.52 nM | PMID10753470 | BindingDB |
Ki | 0.631 nM | PMID10476866 | ChEMBL |
Ki | 2.51 nM | PMID11191833 | BindingDB |
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