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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL182410 |
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Molecular formula | C25H32ClN3O3 |
IUPAC name | 3-[1-[3-(2-chloro-5-methylphenoxy)-2-hydroxyhexyl]piperidin-4-yl]-1H-benzimidazol-2-one |
Molecular weight | 457.999 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 4.7 |
Synonyms | 1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-hexyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one BDBM50159915 |
Inchi Key | AZPDSENEWXRPQS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H32ClN3O3/c1-3-6-23(32-24-15-17(2)9-10-19(24)26)22(30)16-28-13-11-18(12-14-28)29-21-8-5-4-7-20(21)27-25(29)31/h4-5,7-10,15,18,22-23,30H,3,6,11-14,16H2,1-2H3,(H,27,31) |
PubChem CID | 44391133 |
ChEMBL | CHEMBL182410 |
IUPHAR | N/A |
BindingDB | 50159915 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1058.0 nM | PMID15664818 | BindingDB,ChEMBL |
Ki | 20.0 nM | PMID15664818 | BindingDB,ChEMBL |
Response | 97.0 % | PMID15664818 | ChEMBL |
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