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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | spiropiperidine analogue, 39 |
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Molecular formula | C33H38Cl2N4O |
IUPAC name | 8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-(2-piperidin-1-ylethyl)-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 577.594 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 7.2 |
Synonyms | BDBM26918 8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(piperidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one CHEMBL464192 |
Inchi Key | AWCUCKNTBFFHCS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C33H38Cl2N4O/c34-29-15-7-5-13-27(29)31(28-14-6-8-16-30(28)35)37-21-17-33(18-22-37)32(40)38(24-23-36-19-9-2-10-20-36)25-39(33)26-11-3-1-4-12-26/h1,3-8,11-16,31H,2,9-10,17-25H2 |
PubChem CID | 25190597 |
ChEMBL | CHEMBL464192 |
IUPHAR | N/A |
BindingDB | 26918 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 8.0 nM | PMID19147350 | PDSP,BindingDB,ChEMBL |
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