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GPCR

Name	Kappa-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprk1
Synonym	K-OR-1 kappa receptor KOP KOPr KOR-1 OP2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	380
Amino acid sequence	MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
UniProt	P34975
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3614
IUPHAR	318
DrugBank	N/A

Ligand

Name	oxycodone
Molecular formula	C18H21NO4
IUPAC name	(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight	315.369
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.2
Synonyms	Oxycodonum C08018 Oxyneo Codeinone,8-dihydro-14-hydroxy- Percodan (TN) DEA No. 9143 Roxiprin (TN) DTXSID5023407 Thecodine Eucodal ZINC403533 Morphinan-6-one, 4,5-alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- NSC-19043 (-)-Oxycodone Oxicone 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone 0.1 mg/ml in Methanol AC1Q4DTG Apo-oxycodone CR Oxycone Pancodone Retard D05312 PF06 Dihydrohydroxycondeinone Supendol [Canada] Endocet (TN) Tylox (TN) Eutagen Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- (8CI) Ossicodone [DCIT] (5alpha)-14-hydroxy-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one Oxycodeinon 4aH-8,5-bcd]furan-5(6H)-one, 7,7a,8,9-tetrahydro-7a-hydroxy-3-methoxy-12-methyl- Oxycodone Hcl Oxycodone [USAN:INN:BAN] BRN 0043446 Oxyfast Codeinone, dihydro-14-hydroxy- Percocet (TN) Roxicet (TN) Dinarkon Tekodin Eubine Xtampza Hydroxycodeinon Morphinan-6-one,5.alpha.-epoxy-14-hydroxy-3-methoxy-17-methyl- Oxicodona [INN-Spanish] 14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one 76-42-6 Oxycodonum [INN-Latin] CD35PMG570 Oxynorm Combunox (TN) Percolone Dihydro-14-hydroxycodeinone SCHEMBL2737 EINECS 200-960-2 Thekodin Eucodalum Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)- NSC19043 (1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0;{1,13}.0;{5,17}.0;{7,18}]octadeca-7(18),8,10-trien-14-one Oxiconum 4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone 1.0 mg/ml in Methanol AKOS015962233 Avridi Oxycontin CHEMBL656 Pancodone retard (United Kingdom) D0J0TD PTI-821 Dihydrone Supeudol Endodan (TN) UNII-CD35PMG570 GTPL7093 Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-(8CI) Oxanest 124-90-3 Oxycodeinone Oxycodone hydrochloride Oxycodone/ naloxone controlled release BRUQQQPBMZOVGD-XFKAJCMBSA-N OxyIR Codeinone, dihydrohydroxy- Percodan DB00497 Roxicodone Diphydrone Tekodin (free base) Eubine [France] Xtampza ER LS-92148 NSC 19043 (-)-14-Hydroxydihydrocodeinone Oxicon 14-Hydroxydihydrocodeinone Oxycodone (USAN/INN) AC-16043 Oxycon CHEBI:7852 Pancodine D03SKD PF-00345439 Dihydrohydroxycodeinone Supendol Endine (Australia) Theocodin Eukodal Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- Ossicodone (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Oxikon 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone Concentrate AN-22961 BDBM50370595 Oxycontin (TN) Codeinone, 7,8-dihydro-14-hydroxy- Percobarb D0P6KE Remoxy Dihydroxycodeinone Tecodin Endone WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JO1 P1 HSDB 3142 Morphinan-6-one,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5.alpha.)- Oxicodona 124-90-3 (hydrochloride) Oxycodon 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine Oxycodone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material [ Show all ]
Inchi Key	BRUQQQPBMZOVGD-XFKAJCMBSA-N
Inchi ID	InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
PubChem CID	5284603
ChEMBL	CHEMBL656
IUPHAR	N/A
BindingDB	50370595
DrugBank	DB00497
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2658.0 nM	PMID16033285	BindingDB,ChEMBL

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