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Name | Kappa-type opioid receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprk1 |
Synonym | K-OR-1 kappa receptor KOP KOPr KOR-1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 380 |
Amino acid sequence | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV |
UniProt | P34975 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3614 |
IUPHAR | 318 |
DrugBank | N/A |
Name | Norbinaltorphimine |
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Molecular formula | C40H43N3O6 |
IUPAC name | (1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol |
Molecular weight | 661.799 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 5 |
XlogP | 3.2 |
Synonyms | 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)- C18130 Lopac0_000806 nor-Binaltorphimine UNII-36OOQ86QM1 [ Show all ] |
Inchi Key | APSUXPSYBJVPPS-YAUKWVCOSA-N |
Inchi ID | InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1 |
PubChem CID | 5480230 |
ChEMBL | CHEMBL573214 |
IUPHAR | 1642 |
BindingDB | 82551 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Fana | 1.0 - | PMID9836606 | ChEMBL |
Fmut | 9.3 - | PMID9836606 | ChEMBL |
Fmut | 123.0 - | PMID9836606 | ChEMBL |
Fmut | 800.0 - | PMID9836606 | ChEMBL |
Ki | 0.0199526 - 0.251189 nM | PMID8240267, PMID8240268, PMID8234341 | IUPHAR |
Ki | 0.07 nM | PMID11300867 | BindingDB,ChEMBL |
Ki | 0.12 nM | PMID9836606 | BindingDB,ChEMBL |
Ki | 0.24 nM | PMID11300867 | BindingDB,ChEMBL |
Ki | 0.244 nM | PMID10893314 | ChEMBL |
Ki | 0.77 nM | PMID9836606 | BindingDB |
Ki | 0.77 nM | PMID9836606 | ChEMBL |
Ki | 1.39 nM | PMID11300867 | BindingDB,ChEMBL |
Ki | 12.5 nM | PMID9836606 | ChEMBL |
Ki | 13.0 nM | PMID9836606 | BindingDB |
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