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| Name | Free fatty acid receptor 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | FFAR1 |
| Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
| Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
| Length | 300 |
| Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
| UniProt | O14842 |
| Protein Data Bank | 5tzy, 5tzr |
| GPCR-HGmod model | O14842 |
| 3D structure model | This structure is from PDB ID 5tzy. |
| BioLiP | BL0380462, BL0380463, BL0380464 |
| Therapeutic Target Database | T25608 |
| ChEMBL | CHEMBL4422 |
| IUPHAR | 225 |
| DrugBank | BE0000688 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 598 |  CHEMBL3265141 | C33H39FO5 | 534.668 | 6 / 1 | 7.5 | No |
| 746 |  CHEMBL1688475 | C25H26O4 | 390.479 | 4 / 1 | 5.5 | No |
| 816 |  CHEMBL204455 | C23H21NO3 | 359.425 | 4 / 2 | 4.6 | Yes |
| 817 |  carboxylic acid agonist, 14 | C23H21NO3 | 359.425 | 4 / 2 | 4.6 | Yes |
| 818 |  CHEMBL207753 | C23H21NO3 | 359.425 | 4 / 2 | 4.6 | Yes |
| 885 |  CHEMBL3286417 | C19H22O4 | 314.381 | 4 / 1 | 3.3 | Yes |
| 521491 |  CHEMBL3780505 | C20H17NO5 | 351.358 | 6 / 1 | 2.8 | Yes |
| 1710 |  BDBM50306383 | C19H14N2O3S | 350.392 | 5 / 2 | 4.1 | Yes |
| 2206 |  CHEMBL597222 | C17H14Cl2N2O3 | 365.21 | 3 / 1 | 3.9 | Yes |
| 2402 |  CHEMBL1688486 | C24H24O3 | 360.453 | 3 / 1 | 5.5 | No |
| 547936 |  CHEMBL3979588 | C20H13FN2O3S | 380.393 | 6 / 0 | 3.5 | Yes |
| 547937 |  CHEMBL3971461 | C18H13FN2O3S | 356.371 | 6 / 0 | 2.8 | Yes |
| 3456 |  CHEMBL380504 | C22H21F3N2O2S | 434.477 | 8 / 2 | 5.7 | No |
| 521543 |  CHEMBL3759448 | C21H21N3O3S | 395.477 | 5 / 1 | 3.8 | Yes |
| 4160 |  CHEMBL2048627 | C30H34FNO6S | 555.661 | 8 / 3 | 4.6 | No |
| 4329 |  CID 46231597 | C19H16N2O3S | 352.408 | 5 / 1 | 4.0 | Yes |
| 463493 |  CHEMBL3604067 | C20H20F3NO4 | 395.378 | 8 / 1 | 3.5 | Yes |
| 547956 |  CHEMBL3921062 | C19H14F4O4 | 382.311 | 8 / 1 | 5.6 | No |
| 557421 |  SCHEMBL17419035 | C27H28FN3O4 | 477.536 | 8 / 1 | 4.6 | Yes |
| 6093 |  CHEMBL2381280 | C25H19F3O5 | 456.417 | 8 / 1 | 5.0 | Yes |
| 547961 |  CHEMBL3968537 | C21H20O4 | 336.387 | 4 / 1 | 4.6 | Yes |
| 6318 |  DIDODECANOYLPHLOROGLUCINOL | C30H50O5 | 490.725 | 5 / 3 | 11.6 | No |
| 6798 |  CHEMBL2022245 | C28H30O3 | 414.545 | 3 / 1 | 7.0 | No |
| 521643 |  CHEMBL3799898 | C21H19ClFNO4 | 403.834 | 6 / 1 | 4.7 | Yes |
| 536168 |  CHEMBL3883407 | C28H27FO4 | 446.518 | 5 / 1 | 6.2 | No |
| 463824 |  CHEMBL3616657 | C17H16FNO5 | 333.315 | 6 / 2 | 2.8 | Yes |
| 7767 |  CHEMBL205434 | C21H17F3N2O2S | 418.434 | 8 / 2 | 5.4 | No |
| 521667 |  CHEMBL3780627 | C21H20N2O4 | 364.401 | 5 / 1 | 3.1 | Yes |
| 7829 |  CHEMBL2386357 | C16H13NO2 | 251.285 | 3 / 1 | 2.7 | Yes |
| 8794 |  CHEMBL485131 | C23H24N2O3S | 408.516 | 5 / 1 | 4.7 | Yes |
| 8966 |  CHEMBL2315528 | C19H15NO2 | 289.334 | 3 / 1 | 3.4 | Yes |
| 521715 |  CHEMBL3741030 | C17H14ClN3O | 311.769 | 4 / 0 | 3.4 | Yes |
| 9514 |  CHEMBL206572 | C21H19NO3S | 365.447 | 5 / 2 | 5.0 | Yes |
| 521718 |  CHEMBL3780713 | C21H18ClNO4S | 415.888 | 6 / 1 | 4.4 | Yes |
| 10520 |  CHEMBL2152069 | C26H25FO4 | 420.48 | 5 / 1 | 5.7 | No |
| 10844 |  BDBM50306362 | C18H17NO3S | 327.398 | 4 / 2 | 4.3 | Yes |
| 11849 |  CHEMBL2022258 | C26H26O4 | 402.49 | 4 / 1 | 5.4 | No |
| 548018 |  CHEMBL3944507 | C19H19FO4 | 330.355 | 5 / 1 | 4.0 | Yes |
| 12026 |  CHEMBL2047155 | C30H32O7S | 536.639 | 7 / 1 | 4.9 | No |
| 12028 |  CHEMBL2047156 | C30H32O7S | 536.639 | 7 / 1 | 4.9 | No |
| 12030 |  CHEMBL2047154 | C30H32O7S | 536.639 | 7 / 1 | 4.9 | No |
| 12098 |  BDBM50306379 | C17H13F3N2O3S | 382.357 | 8 / 2 | 4.1 | Yes |
| 12114 |  CHEMBL382831 | C22H20F3N3OS | 431.477 | 7 / 2 | 4.5 | Yes |
| 521817 |  CHEMBL3806055 | C20H19N3O4S | 397.449 | 7 / 2 | 3.2 | Yes |
| 464457 |  CHEMBL3600998 | C19H17NO4 | 323.348 | 5 / 1 | 3.3 | Yes |
| 521843 |  CHEMBL3739712 | C17H12F3N3O | 331.298 | 7 / 0 | 3.0 | Yes |
| 536345 |  CHEMBL50273 | C18H21N7O3 | 383.412 | 6 / 4 | 1.6 | Yes |
| 13746 |  CHEMBL2381304 | C28H26ClFO8S | 577.016 | 9 / 1 | 4.5 | No |
| 13966 |  CHEMBL520102 | C16H12O8 | 332.264 | 8 / 6 | 2.2 | No |
| 521880 |  CHEMBL3741349 | C18H11F6N3O2 | 415.295 | 11 / 0 | 4.0 | No |
| 548045 |  CHEMBL3980036 | C23H22O4 | 362.425 | 4 / 1 | 4.8 | Yes |
| 15133 |  CHEMBL1829146 | C17H15NO2 | 265.312 | 3 / 1 | 3.1 | Yes |
| 15559 |  CHEMBL2022256 | C32H30O5 | 494.587 | 5 / 1 | 6.5 | No |
| 15878 |  CHEMBL508388 | C25H24N2O4 | 416.477 | 6 / 1 | 5.6 | No |
| 17691 |  CHEMBL443716 | C38H66O5 | 602.941 | 5 / 3 | 16.0 | No |
| 17695 |  carboxylic acid agonist, 20 | C23H21NO2 | 343.426 | 3 / 2 | 4.7 | Yes |
| 548109 |  CHEMBL3914686 | C30H33NO4S | 503.657 | 6 / 1 | 2.9 | No |
| 19613 |  CHEMBL2386369 | C21H21FO5S | 404.452 | 6 / 1 | 2.8 | Yes |
| 522041 |  CHEMBL3805246 | C20H19N3O4S | 397.449 | 7 / 2 | 3.2 | Yes |
| 19697 |  CHEMBL1688472 | C25H26O3 | 374.48 | 3 / 1 | 5.8 | No |
| 557884 |  SCHEMBL17418599 | C29H27FN2O4S | 518.603 | 8 / 1 | 5.4 | No |
| 19902 |  CHEMBL2047160 | C32H35NO6 | 529.633 | 6 / 1 | 4.9 | No |
| 465396 |  CHEMBL3601053 | C18H16N2O4 | 324.336 | 6 / 1 | 3.1 | Yes |
| 557904 |  SCHEMBL17418781 | C27H29FN2O5 | 480.536 | 8 / 1 | 4.8 | Yes |
| 21458 |  carboxylic acid agonist, 32 | C16H16FNO2 | 273.307 | 4 / 2 | 3.3 | Yes |
| 522223 |  CHEMBL3805558 | C18H14ClN3O3S | 387.838 | 6 / 2 | 3.6 | Yes |
| 442573 |  CHEMBL3330548 | C26H23F3N2O4 | 484.475 | 9 / 1 | 6.0 | No |
| 442576 |  CHEMBL3353744 | C29H33FO7S | 544.634 | 8 / 1 | 5.7 | No |
| 23531 |  CHEMBL2315249 | C18H16O3 | 280.323 | 3 / 2 | 2.8 | Yes |
| 23994 |  CHEMBL2022243 | C26H26O3 | 386.491 | 3 / 1 | 5.9 | No |
| 465893 |  CHEMBL3600994 | C19H16ClNO4 | 357.79 | 5 / 1 | 3.9 | Yes |
| 24124 |  BDBM50306406 | C17H15NO3S | 313.371 | 4 / 2 | 3.9 | Yes |
| 465897 |  CHEMBL3616647 | C15H12FNO4 | 289.262 | 5 / 2 | 2.1 | Yes |
| 442619 |  CHEMBL3330550 | C33H31FN2O3 | 522.62 | 6 / 1 | 7.6 | No |
| 522312 |  CHEMBL3779936 | C24H25NO7S | 471.524 | 9 / 1 | 3.7 | Yes |
| 522318 |  CHEMBL3753790 | C27H26N2O4 | 442.515 | 5 / 1 | 4.3 | Yes |
| 25073 |  BDBM50306398 | C16H13NO3S | 299.344 | 4 / 2 | 3.6 | Yes |
| 522327 |  CHEMBL3800255 | C25H28FNO5 | 441.499 | 7 / 1 | 5.4 | No |
| 25328 |  CHEMBL2151293 | C27H29FO4 | 436.523 | 5 / 1 | 6.5 | No |
| 522336 |  CHEMBL3758885 | C21H19N3O3S | 393.461 | 5 / 1 | 3.8 | Yes |
| 26238 |  carboxylic acid agonist, 44 | C17H20N2O4S | 348.417 | 6 / 3 | 2.1 | Yes |
| 27585 |  CHEMBL3287574 | C24H19F3N2O4S | 488.481 | 10 / 1 | 5.1 | No |
| 28042 |  CHEMBL2385476 | C32H33FO4 | 500.61 | 5 / 1 | 7.3 | No |
| 28214 |  CHEMBL1829153 | C16H13ClN2O2 | 300.742 | 4 / 1 | 3.4 | Yes |
| 522407 |  SCHEMBL3450989 | C20H17NO4S | 367.419 | 6 / 1 | 3.4 | Yes |
| 466428 |  CHEMBL3601007 | C18H16N2O4 | 324.336 | 6 / 1 | 3.1 | Yes |
| 29015 |  CHEMBL1773248 | C17H18O2 | 254.329 | 2 / 1 | 4.1 | Yes |
| 466503 |  CHEMBL3616652 | C17H16FNO5 | 333.315 | 6 / 2 | 2.9 | Yes |
| 522442 |  CHEMBL3754524 | C27H26N2O4 | 442.515 | 5 / 1 | 4.3 | Yes |
| 29892 |  BDBM50306399 | C16H13NO3S | 299.344 | 4 / 2 | 3.6 | Yes |
| 536746 |  CHEMBL192564 | C16H19ClINO2 | 419.687 | 3 / 0 | 3.9 | Yes |
| 522466 |  CHEMBL3780732 | C30H29NO5 | 483.564 | 5 / 1 | 5.3 | No |
| 466681 |  CHEMBL3604033 | C18H19Cl2NO3 | 368.254 | 4 / 2 | 4.2 | Yes |
| 30893 |  CHEMBL203297 | C23H22N2O3 | 374.44 | 4 / 3 | 3.9 | Yes |
| 548231 |  CHEMBL3946820 | C21H22FNO4 | 371.408 | 6 / 1 | 4.1 | Yes |
| 522489 |  CHEMBL3758197 | C22H23N3O3S | 409.504 | 5 / 1 | 4.3 | Yes |
| 31317 |  CHEMBL2381302 | C28H26ClFO8S | 577.016 | 9 / 1 | 4.5 | No |
| 522504 |  3-(4-ethynylphenyl)propanoic acid | C11H10O2 | 174.199 | 2 / 1 | 2.1 | Yes |
| 32479 |  BDBM50306400 | C16H13NO2S2 | 315.405 | 4 / 2 | 4.1 | Yes |
| 548271 |  CHEMBL3924759 | C18H19ClO4 | 334.796 | 4 / 1 | 4.7 | Yes |
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